| |  Online-Ressource |
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| Verfasst von: | Park, Eugene [VerfasserIn]  |
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| | Gang, Eun Ji [VerfasserIn] |
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| | Hsieh, Yao-Te [VerfasserIn] |
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| | Schaefer, Paul [VerfasserIn] |
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| | Chae, Sanna [VerfasserIn] |
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| | Klemm, Lars [VerfasserIn] |
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| | Huantes, Sandra [VerfasserIn] |
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| | Loh, Mignon [VerfasserIn] |
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| | Conway, Edward M. [VerfasserIn] |
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| | Kang, Eun-Suk [VerfasserIn] |
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| | Hoe Koo, Hong [VerfasserIn] |
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| | Hofmann, Wolf-Karsten [VerfasserIn] |
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| | Heisterkamp, Nora [VerfasserIn] |
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| | Pelus, Louis [VerfasserIn] |
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| | Keerthivasan, Ganesan [VerfasserIn] |
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| | Crispino, John [VerfasserIn] |
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| | Kahn, Michael [VerfasserIn] |
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| | Müschen, Markus [VerfasserIn] |
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| | Kim, Yong-Mi [VerfasserIn] |
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| Titel: | Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia |
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| Verf.angabe: | Eugene Park, Eun Ji Gang, Yao-Te Hsieh, Paul Schaefer, Sanna Chae, Lars Klemm, Sandra Huantes, Mignon Loh, Edward M. Conway, Eun-Suk Kang, Hong Hoe Koo, Wolf-Karsten Hofmann, Nora Heisterkamp, Louis Pelus, Ganesan Keerthivasan, John Crispino, Michael Kahn, Markus Müschen, and Yong-Mi Kim |
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| E-Jahr: | 2011 |
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| Jahr: | June 28, 2011 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 09.09.2022 |
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| Titel Quelle: | Enthalten in: Blood |
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| Ort Quelle: | Washington, DC : American Society of Hematology, 1946 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 118(2011), 8, Seite 2191-2199 |
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| ISSN Quelle: | 1528-0020 |
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| Abstract: | Relapse of drug-resistant acute lymphoblastic leukemia (ALL) has been associated with increased expression of survivin/BIRC5, an inhibitor of apoptosis protein, suggesting a survival advantage for ALL cells. In the present study, we report that inhibition of survivin in patient-derived ALL can eradicate leukemia. Targeting survivin with shRNA in combination with chemotherapy resulted in no detectable minimal residual disease in a xenograft model of primary ALL. Similarly, pharmacologic knock-down of survivin using EZN-3042, a novel locked nucleic acid antisense oligonucleotide, in combination with chemotherapy eliminated drug-resistant ALL cells. These findings show the importance of survivin expression in drug resistance and demonstrate that survivin inhibition may represent a powerful approach to overcoming drug resistance and preventing relapse in patients with ALL. |
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| DOI: | doi:10.1182/blood-2011-04-351239 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1182/blood-2011-04-351239 |
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| | DOI: https://doi.org/10.1182/blood-2011-04-351239 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | Combined Modality Therapy |
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| | Drug Resistance, Neoplasm |
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| | Gene Expression |
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| | Gene Targeting |
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| | Humans |
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| | Inhibitor of Apoptosis Proteins |
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| | Mice |
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| | Mice, Inbred NOD |
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| | Mice, Knockout |
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| | Neoplasm, Residual |
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| | Oligonucleotides |
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| | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
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| | Repressor Proteins |
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| | RNA, Small Interfering |
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| | Survivin |
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| | Tumor Stem Cell Assay |
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| | Xenograft Model Antitumor Assays |
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| K10plus-PPN: | 1816366935 |
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| Verknüpfungen: | → Zeitschrift |
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Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia / Park, Eugene [VerfasserIn]; June 28, 2011 (Online-Ressource)
