Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Schreyer, Daniel [VerfasserIn]  |
| Neoptolemos, John P. [VerfasserIn]  |
| Barry, Simon T. [VerfasserIn]  |
| Bailey, Peter [VerfasserIn]  |
Titel: | Deconstructing pancreatic cancer using next generation-omic technologies |
Titelzusatz: | from discovery to knowledge-guided platforms for better patient management |
Verf.angabe: | Daniel Schreyer, John P. Neoptolemos, Simon T. Barry and Peter Bailey |
E-Jahr: | 2022 |
Jahr: | 13 January 2022 |
Umfang: | 15 S. |
Fussnoten: | Gesehen am 12.09.2022 |
Titel Quelle: | Enthalten in: Frontiers in cell and developmental biology |
Ort Quelle: | Lausanne : Frontiers Media, 2013 |
Jahr Quelle: | 2022 |
Band/Heft Quelle: | 9(2022), Artikel-ID 795735, Seite 1-15 |
ISSN Quelle: | 2296-634X |
Abstract: | Comprehensive molecular landscaping studies reveal a potentially brighter future for pancreatic ductal adenocarcinoma (PDAC) patients. Blood-borne biomarkers obtained from minimally invasive “liquid biopsies” are now being trialled for early disease detection and to track responses to therapy. Integrated genomic and transcriptomic studies using resectable tumour material have defined intrinsic patient subtypes and actionable genomic segments that promise a shift towards genome-guided patient management. Multimodal mapping of PDAC using spatially resolved single cell transcriptomics and imaging techniques has identified new potentially therapeutically actionable cellular targets and is providing new insights into PDAC tumour heterogeneity. Despite these rapid advances, defining biomarkers for patient selection remain limited. This review examines the current PDAC cancer biomarker ecosystem (identified in tumour and blood) and explores how advances in single cell sequencing and spatially resolved imaging modalities are being used to uncover new targets for therapeutic intervention and are transforming our understanding of this difficult to treat disease. |
DOI: | doi:10.3389/fcell.2021.795735 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3389/fcell.2021.795735 |
| Volltext: https://www.frontiersin.org/articles/10.3389/fcell.2021.795735 |
| DOI: https://doi.org/10.3389/fcell.2021.795735 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1816418005 |
Verknüpfungen: | → Zeitschrift |
Deconstructing pancreatic cancer using next generation-omic technologies / Schreyer, Daniel [VerfasserIn]; 13 January 2022 (Online-Ressource)
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