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Status: Bibliographieeintrag

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Verfasst von:Muley, Thomas [VerfasserIn]   i
 Kurz, Markus [VerfasserIn]   i
 Männle, Clemens [VerfasserIn]   i
 Alekozai, Adjmal [VerfasserIn]   i
 Winteroll, Susanne [VerfasserIn]   i
 Dienemann, Hendrik [VerfasserIn]   i
 Schmidt, Werner [VerfasserIn]   i
 Pfannschmidt, Joachim [VerfasserIn]   i
Titel:Comparison of serum cardiac specific biomarker release after non-cardiac thoracic surgery
Verf.angabe:Thomas Muley, Markus Kurz, Clemens Männle, Adjmal Alekozai, Susanne Winteroll, Hendrik Dienemann, Werner Schmidt, Joachim Pfannschmidt
Jahr:2011
Umfang:8 S.
Fussnoten:Gesehen am 14.09.2022
Titel Quelle:Enthalten in: Clinical laboratory
Ort Quelle:Heidelberg : Clin Lab Publ., Verl. Klinisches Labor, 1992
Jahr Quelle:2011
Band/Heft Quelle:57(2011), 11/12, Seite 925-932
Abstract:BACKGROUND: The detection of postoperative myocardial infarction can be difficult in patients after lung surgery. The aim of this study was to verify the clinical significance of elevated Troponin I (cTnI), N-terminal pro-natriuretic peptide (NT-pro-BNP), lactate dehydrogenase (LDH), creatine kinase (CK), and CK-MB in the perioperative course. - METHODS: Between 2007 and 2010, 64 patients (36 men, 28 women) were includeded in this prospective study and underwent thoracotomy and wedge lung resection (n = 20, group I), lobectomy/bilobectomy (n = 24, group II), and pneumonectomy (n = 20, group III). Peri-operative measurements were done for the serum markers: cTnI, NT-pro-BNP, LDH, CK, and CK-MB preoperatively and at 4 hours, 8 hours, and 24 hours postoperatively. Patients were followed over a 90-day period to evaluate postoperative cardiac mortality. - RESULTS: No basal troponin I elevation (or CK-MB) was found prior to surgery. Elevation in concentrations of troponin I (> 0.32 ng/mL) occurring after the procedure were seen in 9 patients. However, there was neither association with 90-day survival, postoperative ECG changes, nor with elevated levels of the other cardiac serum markers. cTnI correlated significantly with intrapericardial procedures in 7 out of 20 patients (Spearman's rank correlation coefficient: 0.406; p < 0.0001). Additionally, of the 20 patients within the pneumonectomy group, 8 patients had postoperative elevated serum cTnI. The grouping of patients into groups I through III was significantly associated with cTnI elevation (Spearman's rank correlation coefficient: 0.455; p < 0.0001). - CONCLUSIONS: Despite the excellent sensitivity of troponin I for detection of acute myocardial infarction the fact remains that troponin I elevations were common after intrapericardial procedures and pneumonectomies. Thus, to differentiate between cardiac ischemia provoked chest pain and wound pain related to thoracotomy remains most difficult. Patients with only marginally elevated cTnI concentrations after intrapericardial resections or pneumonectomy should remain in the intensive care unit and should be followed-up carefully by cardiologists.
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Volltext: https://pubmed.ncbi.nlm.nih.gov/22239023/
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adult
 Aged
 Biomarkers
 Chest Pain
 Creatine Kinase
 Creatine Kinase, MB Form
 Electrocardiography
 False Positive Reactions
 Female
 Humans
 L-Lactate Dehydrogenase
 Male
 Middle Aged
 Myocardial Infarction
 Natriuretic Peptide, Brain
 Pain, Postoperative
 Peptide Fragments
 Pneumonectomy
 Postoperative Complications
 Postoperative Period
 Prospective Studies
 Sensitivity and Specificity
 Thoracotomy
 Troponin I
K10plus-PPN:1816622613
Verknüpfungen:→ Zeitschrift

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