| |  Online-Ressource |
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| Verfasst von: | Reiss, Simon [VerfasserIn]  |
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| | Rebhan, Ilka [VerfasserIn] |
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| | Backes, Perdita [VerfasserIn] |
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| | Romero-Brey, Inés [VerfasserIn] |
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| | Erfle, Holger [VerfasserIn] |
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| | Matula, Petr [VerfasserIn] |
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| | Kaderali, Lars [VerfasserIn] |
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| | Pönisch, Marion [VerfasserIn] |
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| | Blankenburg, Hagen [VerfasserIn] |
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| | Hiet, Marie-Sophie [VerfasserIn] |
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| | Longerich, Thomas [VerfasserIn] |
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| | Diehl, Sarah [VerfasserIn] |
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| | Ramirez, Fidel [VerfasserIn] |
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| | Balla, Tamas [VerfasserIn] |
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| | Rohr, Karl [VerfasserIn] |
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| | Kaul, Artur [VerfasserIn] |
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| | Bühler, Sandra [VerfasserIn] |
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| | Pepperkok, Rainer [VerfasserIn] |
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| | Lengauer, Thomas [VerfasserIn] |
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| | Albrecht, Mario [VerfasserIn] |
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| | Eils, Roland [VerfasserIn] |
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| | Schirmacher, Peter [VerfasserIn] |
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| | Lohmann, Volker [VerfasserIn] |
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| | Bartenschlager, Ralf [VerfasserIn] |
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| Titel: | Recruitment and activation of a lipid kinase by Hepatitis C virus NS5A is essential for integrity of the membranous replication compartment |
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| Verf.angabe: | Simon Reiss, Ilka Rebhan, Perdita Backes, Ines Romero-Brey, Holger Erfle, Petr Matula, Lars Kaderali, Marion Poenisch, Hagen Blankenburg, Marie-Sophie Hiet, Thomas Longerich, Sarah Diehl, Fidel Ramirez, Tamas Balla, Karl Rohr, Artur Kaul, Sandra Bühler, Rainer Pepperkok, Thomas Lengauer, Mario Albrecht, Roland Eils, Peter Schirmacher, Volker Lohmann, and Ralf Bartenschlager |
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| E-Jahr: | 2011 |
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| Jahr: | 19 January 2011 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 14.09.2022 |
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| Titel Quelle: | Enthalten in: Cell host and microbe |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2007 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 9(2011), 1, Seite 32-45 |
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| ISSN Quelle: | 1934-6069 |
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| Abstract: | Hepatitis C virus (HCV) is a major causative agent of chronic liver disease in humans. To gain insight into host factor requirements for HCV replication, we performed a siRNA screen of the human kinome and identified 13 different kinases, including phosphatidylinositol-4 kinase III alpha (PI4KIIIα), as being required for HCV replication. Consistent with elevated levels of the PI4KIIIα product phosphatidylinositol-4-phosphate (PI4P) detected in HCV-infected cultured hepatocytes and liver tissue from chronic hepatitis C patients, the enzymatic activity of PI4KIIIα was critical for HCV replication. Viral nonstructural protein 5A (NS5A) was found to interact with PI4KIIIα and stimulate its kinase activity. The absence of PI4KIIIα activity induced a dramatic change in the ultrastructural morphology of the membranous HCV replication complex. Our analysis suggests that the direct activation of a lipid kinase by HCV NS5A contributes critically to the integrity of the membranous viral replication complex. |
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| DOI: | doi:10.1016/j.chom.2010.12.002 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.chom.2010.12.002 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1931312810004129 |
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| | DOI: https://doi.org/10.1016/j.chom.2010.12.002 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Erscheint auch als : Druck-Ausgabe: Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. - 2011 |
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| K10plus-PPN: | 1816638161 |
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| Verknüpfungen: | → Zeitschrift |
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Recruitment and activation of a lipid kinase by Hepatitis C virus NS5A is essential for integrity of the membranous replication compartment / Reiss, Simon [VerfasserIn]; 19 January 2011 (Online-Ressource)
