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Status: Bibliographieeintrag

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Verfasst von:Küchler, Maike [VerfasserIn]   i
 El-Shafie, Rami [VerfasserIn]   i
 Adeberg, Sebastian [VerfasserIn]   i
 Herfarth, Klaus [VerfasserIn]   i
 König, Laila [VerfasserIn]   i
 Lang, Kristin [VerfasserIn]   i
 Hörner-Rieber, Juliane [VerfasserIn]   i
 Plinkert, Peter K. [VerfasserIn]   i
 Wick, Wolfgang [VerfasserIn]   i
 Sahm, Felix [VerfasserIn]   i
 Sprengel, Simon David [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Bernhardt, Denise [VerfasserIn]   i
Titel:Outcome after radiotherapy for vestibular schwannomas (VS)
Titelzusatz:differences in tumor control, symptoms and quality of life after radiotherapy with photon versus proton therapy
Verf.angabe:Maike Küchler, Rami A. El Shafie, Sebastian Adeberg, Klaus Herfarth, Laila König, Kristin Lang, Juliane Hörner-Rieber, Peter Karl Plinkert, Wolfgang Wick, Felix Sahm, Simon David Sprengel, Jürgen Debus and Denise Bernhardt
E-Jahr:2022
Jahr:10 April 2022
Umfang:17 S.
Fussnoten:This article belongs to the special issue Proton Therapy for CNS Tumors ; Gesehen am 15.09.2022
Titel Quelle:Enthalten in: Cancers
Ort Quelle:Basel : MDPI, 2009
Jahr Quelle:2022
Band/Heft Quelle:14(2022), 8, special issue, Artikel-ID 1916, Seite 1-17
ISSN Quelle:2072-6694
Abstract:Background: To evaluate differences in local tumor control (LC), symptoms and quality of life (QOL) of 261 patients with VS after stereotactic radiosurgery/hypofractionated stereotactic radiotherapy (SRS/HFSRT) vs. fractionated radiotherapy (FRT) vs. fractionated proton therapy (FPT) were studied. Methods: For SRS/HFSRT (n = 149), the median fraction dose applied was 12 Gy. For FRT (n = 87) and FPT (n = 25), the median cumulative doses applied were 57.6 Gy and 54 Gy (RBE), respectively. FRT and FPT used single median doses of 1.8 Gy/Gy (RBE). Median follow-up was 38 months. We investigated dosimetry for organs at risk and analyzed toxicity and QOL by sending out a questionnaire. Results: LC was 99.5% at 12 months after RT with no statistical difference between treatment groups (p = 0.19). LC was significantly lower in NF2 patients (p = 0.004) and in patients with higher tumor extension grade (p = 0.039). The hearing preservation rate was 97% at 12 months after RT with no statistical difference between treatment groups (p = 0.31). Facial and trigeminal nerve affection after RT occurred as mild symptoms with highest toxicity rate in FPT patients. Conclusion: SRS/HFSRT, FRT and FPT for VS show similar overall clinical and functional outcomes. Cranial nerve impairment rates vary, potentially due to selection bias with larger VS in the FRT and FPT group.
DOI:doi:10.3390/cancers14081916
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3390/cancers14081916
 Volltext: https://www.mdpi.com/2072-6694/14/8/1916
 DOI: https://doi.org/10.3390/cancers14081916
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:clinical outcome
 hearing preservation
 proton therapy
 quality of life
 stereotactic radiotherapy
 tumor control
 vestibular schwannomas
K10plus-PPN:1816701823
Verknüpfungen:→ Zeitschrift

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