High-risk human papillomavirus in non-melanoma skin lesions from renal allograft recipients and immunocompetent patients

• Verfasst von: Reuschenbach, Miriam [VerfasserIn]
• Verfasst von: Tran, Thuong Hien [VerfasserIn]
• Verfasst von: Faulstich, F. [VerfasserIn]
• Verfasst von: Hartschuh, Wolfgang [VerfasserIn]
• Verfasst von: Vinokurova, S. [VerfasserIn]
• Verfasst von: Kloor, Matthias [VerfasserIn]
• Verfasst von: Krautkrämer, E. [VerfasserIn]
• Verfasst von: Zeier, Martin [VerfasserIn]
• Verfasst von: Knebel Doeberitz, Magnus von [VerfasserIn]
• Verfasst von: Sommerer, Claudia [VerfasserIn]
• Titel: High-risk human papillomavirus in non-melanoma skin lesions from renal allograft recipients and immunocompetent patients
• Verf.angabe: M. Reuschenbach, T. Tran, F. Faulstich, W. Hartschuh, S. Vinokurova, M. Kloor, E. Krautkrämer, M. Zeier, M. von Knebel Doeberitz and C. Sommerer
• E-Jahr: 2011
• Jahr: 22 March 2011
• Umfang: 8 S.
• Fussnoten: Gesehen am 15.09.2022
• Titel Quelle: Enthalten in: British journal of cancer
• Ort Quelle: Edinburgh : Nature Publ. Group, 1999
• Jahr Quelle: 2011
• Band/Heft Quelle: 104(2011), 8, Seite 1334-1341
• ISSN Quelle: 1532-1827
• DOI: doi:10.1038/bjc.2011.95
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Melanoma
• Sach-SW: Virology
• K10plus-PPN: 1816712191

Abstract

Background: High-risk human papillomaviruses (HR-HPVs) can be detected in a proportion of non-melanoma skin cancers. Data on prevalence are inconclusive, but are essential to estimate the relevance of HR-HPV, particularly with regard to prophylactic HPV vaccines for skin cancer prevention. Methods: High-risk human papillomavirus DNA was investigated in 140 non-melanoma skin lesions from 54 immunocompetent patients and 33 immunosuppressed renal allograft recipients. Expression of p16INK4a, a marker for HR-HPV oncogene expression in the uterine cervix, and of p53 and pRB was evaluated immunohistochemically. Results: The highest prevalence of HR-HPV was found in squamous cell cancer (SCC) (46.2% (6 out of 13) in immunosuppressed and 23.5% (4 out of 17) in immunocompetent patients). High-risk human papillomavirus positivity was accompanied by diffuse p16INK4a expression in most SCC (P<0.001) and basal cell cancers (P=0.02), while almost all SCC in situ were p16INK4a positive irrespective of HR-HPV presence (P=0.66). Diffuse p16INK4a expression was associated with lack of pRB expression (P=0.001). p53 was strongly expressed in 40.0% (56 out of 140) of the lesions irrespective of HR-HPV presence. Conclusion: High-risk human papillomavirus can be detected in lesions of keratinised squamous epithelia. The association of HR-HPV with diffuse p16INK4a expression might indicate HR-HPV oncogene expression in a proportion of lesions. Overexpression of p53 suggests p53 pathway alterations in HR-HPV-positive and -negative lesions.