3 Tesla sodium inversion recovery magnetic resonance imaging allows for improved visualization of intracellular sodium content changes in muscular channelopathies

• Verfasst von: Nagel, Armin Michael [VerfasserIn]
• Verfasst von: Amarteifio, Erick [VerfasserIn]
• Verfasst von: Lehmann-Horn, Frank [VerfasserIn]
• Verfasst von: Jurkat-Rott, Karin [VerfasserIn]
• Verfasst von: Semmler, Wolfhard [VerfasserIn]
• Verfasst von: Schad, Lothar R. [VerfasserIn]
• Verfasst von: Weber, Marc-André [VerfasserIn]
• Titel: 3 Tesla sodium inversion recovery magnetic resonance imaging allows for improved visualization of intracellular sodium content changes in muscular channelopathies
• Verf.angabe: Armin Michael Nagel, PhD, Erick Amarteifio, MD, Frank Lehmann-Horn, MD, Karin Jurkat-Rott, MD, Wolfhard Semmler, MD, PhD, Lothar R. Schad, PhD, and Marc-André Weber, MD
• Jahr: 2011
• Umfang: 8 S.
• Fussnoten: Gesehen am 15.09.2022
• Titel Quelle: Enthalten in: Investigative radiology
• Ort Quelle: Philadelphia, Pa. : Lippincott Williams & Wilkins, 1966
• Jahr Quelle: 2011
• Band/Heft Quelle: 46(2011), 12 vom: Dez., Seite 759-766
• ISSN Quelle: 1536-0210
• DOI: doi:10.1097/RLI.0b013e31822836f6
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1816726478

Abstract

Objectives: - To implement different sodium (23Na)-magnetic resonance imaging (MRI) contrasts at 3 Tesla and to evaluate if a weighting toward intracellular sodium can be achieved, using 2 rare muscular channelopathies as model diseases. - Materials and Methods: - Both lower legs of 6 patients with hypokalemic periodic paralysis (HypoPP), 5 patients with paramyotonia congenita (PC), and 5 healthy volunteers were examined on a 3 Tesla system with 3 different 23Na-MRI pulse sequences. HypoPP and PC are rare muscle diseases, which are well characterized by elevated myoplasmic sodium at rest and after cooling, respectively. Intra- and interindividual comparisons were performed before and after provocation of one lower leg muscle. Three different 23Na-MRI sequences were applied: (i) The total tissue sodium concentration was measured using a spin-density sequence (23Na-TSC). (ii) A T1-contrast was applied to assess whether the known changes of the intracellular sodium concentration can be visualized by T1-weighting (23Na-T1). (iii) An inversion recovery (23Na-IR) sequence was used to utmost suppress the sodium signal from extracellular or vasogenic edema. Furthermore, a potential influence of the temperature dependency of the sodium relaxation times was considered. Additionally, 1H-MRI was performed to examine potential lipomatous or edematous changes. - Results: - In HypoPP, all 23Na sequences showed significantly (P < 0.05) higher signal intensities compared with PC patients and healthy subjects. In muscles of PC patients, provocation induced a significant (P = 0.0007) increase (>20%) in the muscular 23Na-IR signal and a corresponding decrease of muscle strength. Additionally, a tendency to higher 23Na-T1 (P = 0.07) and 23Na-TSC (P = 0.07) signal intensities was observed. Provocation revealed no significant changes in 1H-MRI. In volunteers and in the contralateral, not cooled lower leg, there were no significant signal intensity changes after provocation. Furthermore, the 23Na-IR sequence allows for a suppression of signal emanating from intravascular sodium and vasogenic edema. - Conclusions: - Our results indicate that the 23Na-IR sequence allows for a weighting toward intracellular sodium. The combined application of the 23Na-TSC and the 23Na-IR sequence enables an improved analysis of pathophysiological changes that occur in muscles of patients with muscular channelopathies.