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Verfasst von:Nagel, Simon [VerfasserIn]   i
 Heinemann, Philipp von [VerfasserIn]   i
 Heiland, Sabine [VerfasserIn]   i
 Koziol, J. [VerfasserIn]   i
 Gardner, H. [VerfasserIn]   i
 Wagner, Simone [VerfasserIn]   i
Titel:Selective MMP-inhibition with Ro 28-2653 in acute experimental stroke
Titelzusatz:a magnetic resonance imaging efficacy study
Verf.angabe:S. Nagel, P.v. Heinemann, S. Heiland, J. Koziol, H. Gardner, S. Wagner
Jahr:2011
Umfang:7 S.
Fussnoten:First published online: 21 October 2010 ; Gesehen am 15.09.2022
Titel Quelle:Enthalten in: Brain research
Ort Quelle:Amsterdam : Elsevier, 1966
Jahr Quelle:2011
Band/Heft Quelle:1368(2011), Seite 264-270
ISSN Quelle:1872-6240
Abstract:Blood-brain-barrier (BBB) breakdown due to matrix metalloproteinase (MMP) activity following stroke is often associated with cerebral edema, larger infarct volumes and bad outcome. In the present study we examined a novel MMP-inhibitor (Ro 28-2653) with high selectivity for MMP2, MMP9 and membrane type 1-MMP in an acute stroke model comparing two different treatment regimens. We subjected rats to 90min of focal cerebral ischemia followed by 3days or 7days of reperfusion, respectively, using the middle cerebral artery (MCA) filament occlusion technique. Ro 28-2653 was administered daily in a vehicle solution for 2days or 6days after ischemia, respectively. We assessed the behavior with a functional neuroscore and infarct volumes as well as blood-brain-barrier (BBB) breakdown with magnetic resonance imaging (MRI) after 3 and 7days. Infarct edema volumes, BBB breakdown and behavior at 3days were significantly attenuated in rats treated for 2days with Ro 28-2653 as compared to vehicle and untreated controls. After 6days of treatment however, infarct and BBB breakdown volumes as well as behavior did not differ significantly between the groups at 7days. The new high selective MMP-inhibitor Ro 28-2653 significantly reduced brain injury only when administered in the first 2days after focal cerebral ischemia. Prolonged treatment for 6days did not show any beneficial effects possibly due to interference with protective restorative processes.
DOI:doi:10.1016/j.brainres.2010.10.057
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.brainres.2010.10.057
 Volltext: https://www.sciencedirect.com/science/article/pii/S0006899310023267
 DOI: https://doi.org/10.1016/j.brainres.2010.10.057
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:BBB breakdown
 Focal cerebral ischemia
 Metalloproteinases
 Middle cerebral artery occlusion
 MRI
K10plus-PPN:1816730416
Verknüpfungen:→ Zeitschrift

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