| |  Online-Ressource |
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| Verfasst von: | Pausch, Thomas [VerfasserIn]  |
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| | Liu, Xinchun [VerfasserIn] |
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| | Cui, Jiaqu [VerfasserIn] |
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| | Wei, Jishu [VerfasserIn] |
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| | Miao, Yi [VerfasserIn] |
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| | Heger, Ulrike [VerfasserIn] |
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| | Probst, Pascal [VerfasserIn] |
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| | Heap, Stephen [VerfasserIn] |
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| | Hackert, Thilo [VerfasserIn] |
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| Titel: | Survival benefit of resection surgery for pancreatic ductal adenocarcinoma with liver metastases |
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| Titelzusatz: | a propensity score-matched SEER database analysis |
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| Verf.angabe: | Thomas M. Pausch, Xinchun Liu, Jiaqu Cui, Jishu Wei, Yi Miao, Ulrike Heger, Pascal Probst, Stephen Heap and Thilo Hackert |
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| Jahr: | 2022 |
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| Umfang: | 15 S. |
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| Fussnoten: | Published: 23 December 2021 ; Gesehen am 16.09.2022 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 14(2022), 1, Artikel-ID 57, Seite 1-15 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Guidelines do not recommend resection surgery for oligometastatic pancreatic ductal adenocarcinoma (PDAC). However, reports in small samples of selected patients suggest that surgery extends survival. Thus, this study aims to gather evidence for the benefits of cancer-directed surgery (CDS) by analyzing a national cohort and identifying prognostic factors that aid the selection of candidates for CDS or recruitment into experimental trials. Data for patients with PDAC and hepatic metastasis were extracted from the population-based Surveillance, Epidemiology, and End Results database (SEER). The bias between CDS and non-CDS groups was minimized with Propensity Score Matching (PSM), and the prognostic role of CDS was investigated by comparing Kaplan-Meier estimators and Cox proportional hazard models. A total of 12,018 patients were extracted from the database, including 259 patients who underwent CDS that were 1:1 propensity score-matched with patients who did not receive CDS. CDS appeared to significantly prolong median overall survival from 5 to 10 months. Multivariate analysis revealed chemotherapy as a protective prognostic, whilst survival was impaired by old age and tumors that were poorly differentiated (Grades III-IV). These factors can be used to select patients likely to benefit from CDS treatment, which may facilitate recruitment into randomized controlled trials. |
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| DOI: | doi:10.3390/cancers14010057 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/cancers14010057 |
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| | Volltext: https://www.mdpi.com/2072-6694/14/1/57 |
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| | DOI: https://doi.org/10.3390/cancers14010057 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cancer-directed surgery |
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| | liver metastasis |
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| | overall survival |
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| | pancreatic adenocarcinoma |
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| | SEER |
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| K10plus-PPN: | 1816763527 |
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| Verknüpfungen: | → Zeitschrift |
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Survival benefit of resection surgery for pancreatic ductal adenocarcinoma with liver metastases / Pausch, Thomas [VerfasserIn]; 2022 (Online-Ressource)
