Genome-wide association study identifies five new schizophrenia loci

• Verfasst von: Ripke, Stephan [VerfasserIn]
• Verfasst von: Rietschel, Marcella [VerfasserIn]
• Titel: Genome-wide association study identifies five new schizophrenia loci
• Verf.angabe: The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium; Stephan Ripke, Alan R. Sanders, Kenneth S. Kendler, Douglas F. Levinson, Pamela Sklar, Peter A. Holmans, Dan-Yu Lin, Jubao Duan, Roel A. Ophoff, Ole A. Andreassen, Edward Scolnick, Sven Cichon, David St. Clair, Aiden Corvin, Hugh Gurling, Thomas Werge, Dan Rujescu, Douglas H.R. Blackwood, Carlos N. Pato, Anil K. Malhotra, Shaun Purcell, Frank Dudbridge, Benjamin M. Neale, Lizzy Rossin, Peter M. Visscher, Danielle Posthuma, Douglas M. Ruderfer, Ayman Fanous, Hreinn Stefansson, Stacy Steinberg, Bryan J. Mowry, Vera Golimbet, Marc De Hert, Erik G. Jönsson, István Bitter, Olli P.H. Pietiläinen, David A. Collier, Sarah Tosato, Ingrid Agartz, Margot Albus, Madeline Alexander, Richard L 'Amdur, Farooq Amin, Nicholas Bass, Sarah E. Bergen, Donald W. Black, Anders D. Børglum, Matthew A. Brown, Richard Bruggeman, Nancy G. Buccola, William F. Byerley, Wiepke Cahn, Rita M. Cantor, Vaughan J. Carr, Stanley V. Catts, Khalid Choudhury, C. Robert Cloninger, Paul Cormican, Nicholas Craddock, Patrick A. Danoy, Susmita Datta, Lieuwe de Haan, Ditte Demontis, Dimitris Dikeos, Srdjan Djurovic, Peter Donnelly, Gary Donohoe, Linh Duong, Sarah Dwyer, Anders Fink-Jensen, Robert Freedman, Nelson B. Freimer, Marion Friedl, Lyudmila Georgieva, Ina Giegling, Michael Gill, Birte Glenthøj, Stephanie Godard, Marian Hamshere, Mark Hansen, Thomas Hansen, Annette M. Hartmann, Frans A. Henskens, David M. Hougaard, Christina M. Hultman, Andrés Ingason, Assen V. Jablensky, Klaus D. Jakobsen, Maurice Jay, Gesche Jürgens, René S. Kahn, Matthew C. Keller, Gunter Kenis, Elaine Kenny, Yunjung Kim, George K. Kirov, Heike Konnerth, Bettina Konte, Lydia Krabbendam, Robert Krasucki, Virginia K. Lasseter, Claudine Laurent, Jacob Lawrence, Todd Lencz, F. Bernard Lerer, Kung-Yee Liang, Paul Lichtenstein, Jeffrey A. Lieberman, Don H. Linszen, Jouko Lönnqvist, Carmel M. Loughland, Alan W. Maclean, Brion S. Maher, Wolfgang Maier, Jacques Mallet, Pat Malloy, Manuel Mattheisen, Morten Mattingsdal, Kevin A. McGhee, John J. McGrath, Andrew McIntosh, Duncan E. McLean, Andrew McQuillin, Ingrid Melle, Patricia T. Michie, Vihra Milanova, Derek W. Morris, Ole Mors, Preben B. Mortensen, Valentina Moskvina, Pierandrea Muglia, Inez Myin-Germeys, Deborah A. Nertney, Gerald Nestadt, Jimmi Nielsen, Ivan Nikolov, Merete Nordentoft, Nadine Norton, Markus M. Nöthen, Colm T. O'Dushlaine, Ann Olincy, Line Olsen, F. Anthony O'Neill, Torben F. Ørntoft, Michael J. Owen, Christos Pantelis, George Papadimitriou, Michele T. Pato, Leena Peltonen, Hannes Petursson, Ben Pickard, Jonathan Pimm, Ann E. Pulver, Vinay Puri, Digby Quested, Emma M. Quinn, Henrik B. Rasmussen, János M. Réthelyi, Robert Ribble, Marcella Rietschel, Brien P. Riley, Mirella Ruggeri, Ulrich Schall, Thomas G. Schulze, Sibylle G. Schwab, Rodney J. Scott, Jianxin Shi, Engilbert Sigurdsson, Jeremy M. Silverman, Chris C.A. Spencer, Kari Stefansson, Amy Strange, Eric Strengman, T. Scott Stroup, Jaana Suvisaari, Lars Terenius, Srinivasa Thirumalai, Johan H. Thygesen, Sally Timm, Draga Toncheva, Edwin van den Oord, Jim van Os, Ruud van Winkel, Jan Veldink, Dermot Walsh, August G. Wang, Durk Wiersma, Dieter B. Wildenauer, Hywel J. Williams, Nigel M. Williams, Brandon Wormley, Stan Zammit, Patrick F. Sullivan, Michael C. O'Donovan, Mark J. Daly & Pablo V. Gejman
• E-Jahr: 2011
• Jahr: 18 September 2011
• Umfang: 8 S.
• Fussnoten: Gesehen am 16.09.2022
• Titel Quelle: Enthalten in: Nature genetics
• Ort Quelle: London : Macmillan Publishers Limited, part of Springer Nature, 1992
• Jahr Quelle: 2011
• Band/Heft Quelle: 43(2011), 10, Seite 969-976
• ISSN Quelle: 1546-1718
• DOI: doi:10.1038/ng.940
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Bipolar disorder
• Sach-SW: Disease genetics
• Sach-SW: Genome-wide association studies
• Sach-SW: Schizophrenia
• K10plus-PPN: 1816772585

Abstract

The Schizophrenia Psychiatric Genome-Wide Association Study Consortium reports five genetic loci newly associated with risk of schizophrenia, involving 17,836 cases of schizophrenia and 33,859 healthy controls. The new locus with the strongest support of association was located within an intron for microRNA 137, a known regulator of neuronal development. Four other genome-wide significant loci for schizophrenia contain predicted targets of MIR137, suggesting that disruption to pathways involving MIR137 may be an etiologic mechanism in schizophrenia.