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Verfasst von:Eckardt, Luise [VerfasserIn]   i
 Prange-Barczynska, Maria [VerfasserIn]   i
 Hodson, Emma J. [VerfasserIn]   i
 Fielding, James W. [VerfasserIn]   i
 Cheng, Xiaotong [VerfasserIn]   i
 Lima, Joanna D. C. C. [VerfasserIn]   i
 Kurlekar, Samvid [VerfasserIn]   i
 Douglas, Gillian [VerfasserIn]   i
 Ratcliffe, Peter J. [VerfasserIn]   i
 Bishop, Tammie [VerfasserIn]   i
Titel:Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma
Verf.angabe:Luise Eckardt, Maria Prange-Barczynska, Emma J. Hodson, James W. Fielding, Xiaotong Cheng, Joanna D.C.C. Lima, Samvid Kurlekar, Gillian Douglas, Peter J. Ratcliffe and Tammie Bishop
E-Jahr:2021
Jahr:20 September 2021
Umfang:16 S.
Fussnoten:Gesehen am 16.09.2022
Titel Quelle:Enthalten in: Endocrine related cancer
Ort Quelle:Bristol : Soc. for Endocrinology, 1994
Jahr Quelle:2021
Band/Heft Quelle:28(2021), 12, Seite 757-772
ISSN Quelle:1479-6821
Abstract:Despite a general role for the HIF hydroxylase system in cellular oxygen sensing and tumour hypoxia, cancer-associated mutations of genes in this pathway, including PHD2, PHD1, EPAS1 (encoding HIF-2α) are highly tissue-restricted, being observed in pseudohypoxic pheochromocytoma and paraganglioma (PPGL) but rarely, if ever, in other tumours. In an effort to understand that paradox and gain insights into the pathogenesis of pseudohypoxic PPGL, we constructed mice in which the principal HIF prolyl hydroxylase, Phd2, is inactivated in the adrenal medulla using TH-restricted Cre recombinase. Investigation of these animals revealed a gene expression pattern closely mimicking that of pseudohypoxic PPGL. Spatially resolved analyses demonstrated a binary distribution of two contrasting patterns of gene expression among adrenal medullary cells. Phd2 inactivation resulted in a marked shift in this distribution towards a Pnmt−/Hif-2α+/Rgs5+ population. This was associated with morphological abnormalities of adrenal development, including ectopic TH+ cells within the adrenal cortex and external to the adrenal gland. These changes were ablated by combined inactivation of Phd2 with Hif-2α, but not Hif-1α. However, they could not be reproduced by inactivation of Phd2 in adult life, suggesting that they arise from dysregulation of this pathway during adrenal development. Together with the clinical observation that pseudohypoxic PPGL manifests remarkably high heritability, our findings suggest that this type of tumour likely arises from dysregulation of a tissue-restricted action of the PHD2/HIF-2α pathway affecting adrenal development in early life and provides a model for the study of the relevant processes.
DOI:doi:10.1530/ERC-21-0211
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1530/ERC-21-0211
 Volltext: https://erc.bioscientifica.com/view/journals/erc/28/12/ERC-21-0211.xml
 DOI: https://doi.org/10.1530/ERC-21-0211
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1816774766
Verknüpfungen:→ Zeitschrift

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