| |  Online-Ressource |
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| Verfasst von: | Rodrigues, Pedro N. S. [VerfasserIn]  |
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| | Gomes, Sandro S. [VerfasserIn] |
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| | Neves, João V. [VerfasserIn] |
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| | Gomes-Pereira, Sandra [VerfasserIn] |
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| | Correia-Neves, Margarida [VerfasserIn] |
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| | Nunes-Alves, Cláudio [VerfasserIn] |
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| | Stolte, Jens [VerfasserIn] |
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| | Sanchez, Mayka [VerfasserIn] |
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| | Appelberg, Rui [VerfasserIn] |
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| | Muckenthaler, Martina [VerfasserIn] |
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| | Gomes, M. Salomé [VerfasserIn] |
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| Titel: | Mycobacteria-induced anaemia revisited |
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| Titelzusatz: | a molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin |
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| Verf.angabe: | Pedro N. Rodrigues, Sandro S. Gomes, João V. Neves, Sandra Gomes-Pereira, Margarida Correia-Neves, Cláudio Nunes-Alves, Jens Stolte, Mayka Sanchez, Rui Appelberg, Martina U. Muckenthaler, M. Salomé Gomes |
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| E-Jahr: | 2011 |
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| Jahr: | 20 April 2011 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 19.09.2022 |
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| Titel Quelle: | Enthalten in: Immunobiology |
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| Ort Quelle: | München : Elsevier, 1979 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 216(2011), 10, Seite 1127-1134 |
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| ISSN Quelle: | 1878-3279 |
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| Abstract: | Anaemia is a frequent complication of chronic infectious diseases but the exact mechanisms by which it develops remain to be clarified. In the present work, we used a mouse model of mycobacterial infection to study molecular alterations of iron metabolism induced by infection. We show that four weeks after infection with Mycobacterium avium BALB/c mice exhibited a moderate anaemia, which was not accompanied by an increase on hepatic hepcidin mRNA expression. Instead, infected mice presented increased mRNA expression of ferroportin (Slc40a1), ceruloplasmin (Cp), hemopexin (Hpx), heme-oxygenase-1 (Hmox1) and lipocalin-2 (Lcn2). Both the anaemia and the mRNA expression changes of iron-related genes were largely absent in C.D2 mice which bear a functional allele of the Nramp1 gene. Data presented in this work suggest that anaemia due to a chronic mycobacterial infection may develop in the absence of elevated hepcidin expression, is influenced by Nramp1 and may involve lipocalin-2. |
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| DOI: | doi:10.1016/j.imbio.2011.04.004 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.imbio.2011.04.004 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0171298511000751 |
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| | DOI: https://doi.org/10.1016/j.imbio.2011.04.004 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Anaemia |
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| | Hepcidin |
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| | Lipocalin-2 |
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| | Mycobacteria |
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| | NRAMP1 |
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| K10plus-PPN: | 1816932302 |
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| Verknüpfungen: | → Zeitschrift |
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Mycobacteria-induced anaemia revisited / Rodrigues, Pedro N. S. [VerfasserIn]; 20 April 2011 (Online-Ressource)
