Temporal association of acute hepatitis A and Plasmodium falciparum malaria in children

• Verfasst von: Klein Klouwenberg, Peter [VerfasserIn]
• Verfasst von: Sasi, Philip [VerfasserIn]
• Verfasst von: Bashraheil, Mahfudh [VerfasserIn]
• Verfasst von: Awuondo, Ken [VerfasserIn]
• Verfasst von: Bonten, Marc [VerfasserIn]
• Verfasst von: Berkley, James [VerfasserIn]
• Verfasst von: Marsh, Kevin [VerfasserIn]
• Verfasst von: Borrmann, Steffen [VerfasserIn]
• Titel: Temporal association of acute hepatitis A and Plasmodium falciparum malaria in children
• Verf.angabe: Peter Klein Klouwenberg, Philip Sasi, Mahfudh Bashraheil, Ken Awuondo, Marc Bonten, James Berkley, Kevin Marsh, Steffen Borrmann
• E-Jahr: 2011
• Jahr: July 6, 2011
• Umfang: 5 S.
• Fussnoten: Gesehen am 19.09.2022
• Titel Quelle: Enthalten in: PLOS ONE
• Ort Quelle: San Francisco, California, US : PLOS, 2006
• Jahr Quelle: 2011
• Band/Heft Quelle: 6(2011), 7, Artikel-ID e21013, Seite 1-5
• ISSN Quelle: 1932-6203
• DOI: doi:10.1371/journal.pone.0021013
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Children
• Sach-SW: Epidemiology
• Sach-SW: Hepatitis A virus
• Sach-SW: Malaria
• Sach-SW: Malarial parasites
• Sach-SW: Parasitemia
• Sach-SW: Parasitic diseases
• Sach-SW: Plasmodium
• K10plus-PPN: 1816935689

Abstract

Background: In sub-Saharan Africa, Plasmodium falciparum and hepatitis A (HAV) infections are common, especially in children. Co-infections with these two pathogens may therefore occur, but it is unknown if temporal clustering exists. Materials and Methods We studied the pattern of co-infection of P. falciparum malaria and acute HAV in Kenyan children under the age of 5 years in a cohort of children presenting with uncomplicated P. falciparum malaria. HAV status was determined during a 3-month follow-up period. Discussion Among 222 cases of uncomplicated malaria, 10 patients were anti-HAV IgM positive. The incidence of HAV infections during P. falciparum malaria was 1.7 (95% CI 0.81-3.1) infections/person-year while the cumulative incidence of HAV over the 3-month follow-up period was 0.27 (95% CI 0.14-0.50) infections/person-year. Children with or without HAV co-infections had similar mean P. falciparum asexual parasite densities at presentation (31,000/µL vs. 34,000/µL, respectively), largely exceeding the pyrogenic threshold of 2,500 parasites/µL in this population and minimizing risk of over-diagnosis of malaria as an explanation. Conclusion The observed temporal association between acute HAV and P. falciparum malaria suggests that co-infections of these two hepatotrophic human pathogens may result from changes in host susceptibility. Testing this hypothesis will require larger prospective studies.