Recent advances in “sickle and niche” research

• Verfasst von: Torres, Lidiane S. [VerfasserIn]
• Verfasst von: Asada, Noboru [VerfasserIn]
• Verfasst von: Weiss, Mitchell J. [VerfasserIn]
• Verfasst von: Trumpp, Andreas [VerfasserIn]
• Verfasst von: Suda, Toshio [VerfasserIn]
• Verfasst von: Scadden, David T. [VerfasserIn]
• Verfasst von: Ito, Keisuke [VerfasserIn]
• Titel: Recent advances in “sickle and niche” research
• Titelzusatz: tribute to Dr. Paul S Frenette
• Gefeierte Person: Frenette, Paul S. [GefeierteR]
• Verf.angabe: Lidiane S. Torres, Noboru Asada, Mitchell J. Weiss, Andreas Trumpp, Toshio Suda, David T. Scadden, and Keisuke Ito
• E-Jahr: 2022
• Jahr: 12 July 2022
• Umfang: 27 S.
• Fussnoten: Gesehen am 20.09.2022
• Titel Quelle: Enthalten in: Stem cell reports
• Ort Quelle: Maryland Heights, MO : Cell Press, 2013
• Jahr Quelle: 2022
• Band/Heft Quelle: 17(2022), 7, Seite 1509-1535
• ISSN Quelle: 2213-6711
• DOI: doi:10.1016/j.stemcr.2022.06.004
• Datenträger: Online-Ressource
• Dokumenttyp: Festschrift
• Sprache: eng
• K10plus-PPN: 1816982385

Abstract

In this retrospective, we review the two research topics that formed the basis of the outstanding career of Dr. Paul S. Frenette. In the first part, we focus on sickle cell disease (SCD). The defining feature of SCD is polymerization of the deoxygenated mutant hemoglobin, which leads to a vicious cycle of hemolysis and vaso-occlusion. We survey important discoveries in SCD pathophysiology that have led to recent advances in treatment of SCD. The second part focuses on the hematopoietic stem cell (HSC) niche, the complex microenvironment within the bone marrow that controls HSC function and homeostasis. We detail the cells that constitute this niche, and the factors that these cells use to exert control over hematopoiesis. Here, we trace the scientific paths of Dr. Frenette, highlight key aspects of his research, and identify his most important scientific contributions in both fields.