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Verfasst von:Neuber, Brigitte [VerfasserIn]   i
 Krämer, Isabelle [VerfasserIn]   i
 Tolliver, Claudia [VerfasserIn]   i
 Schönland, Stefan [VerfasserIn]   i
 Hegenbart, Ute [VerfasserIn]   i
 Hose, Dirk [VerfasserIn]   i
 Witzens-Harig, Mathias [VerfasserIn]   i
 Ho, Anthony Dick [VerfasserIn]   i
 Goldschmidt, Hartmut [VerfasserIn]   i
 Klein, Bernard [VerfasserIn]   i
 Hundemer, Michael [VerfasserIn]   i
Titel:Lenalidomide enhances antigen-specific activity and decreases CD45RA expression of T cells from patients with multiple myeloma
Verf.angabe:Brigitte Neuber, Isabelle Herth, Claudia Tolliver, Stefan Schoenland, Ute Hegenbart, Dirk Hose, Mathias Witzens-Harig, Anthony D. Ho, Hartmut Goldschmidt, Bernard Klein and Michael Hundemer
E-Jahr:2011
Jahr:July 6, 2011
Umfang:10 S.
Fussnoten:Gesehen am 21.09.2022
Titel Quelle:Enthalten in: The journal of immunology
Ort Quelle:Bethesda, Md. : Soc., 1916
Jahr Quelle:2011
Band/Heft Quelle:187(2011), 2, Seite 1047-1056
ISSN Quelle:1550-6606
Abstract:The aim of this study was to investigate whether the specific T cell response against the multiple myeloma Ag HM1.24 is enhanced by the immunomodulatory drug lenalidomide (Revlimid). Ag-specific CD3+CD8+ T cells against the HM1.24 Ag were expanded in vitro by dendritic cells in 29 healthy donors and 26 patients with plasma cell dyscrasias. Ag-specific activation was analyzed by IFN-γ, granzyme B, and perforin secretion using ELISA, ELISPOT assay, and intracellular staining, and generation of Ag-specific T cells was analyzed by tetramer staining. Expression of T cell maturation markers (CD45RA, CD45R0, CCR7, and CD28) was investigated by flow cytometry. We found that activation of HM1.24-specific T cells from healthy donors and patients with plasma cell dyscrasias was enhanced significantly by lenalidomide and furthermore that the impact of lenalidomide on T cells depends on the duration of the exposure. Notably, lenalidomide supports the downregulation of CD45RA on T cells upon activation, observed in healthy donors and in patients in vitro and also in patients during lenalidomide therapy in vivo. We showed for the first time, to our knowledge, that lenalidomide enhances the Ag-specific activation of T cells and the subsequent downregulation of CD45RA expression of T cells in vitro and in vivo.
DOI:doi:10.4049/jimmunol.1002460
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.4049/jimmunol.1002460
 Volltext: https://www.jimmunol.org/content/187/2/1047
 DOI: https://doi.org/10.4049/jimmunol.1002460
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:181722123X
Verknüpfungen:→ Zeitschrift

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