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Verfasst von:Karger, Christian [VerfasserIn]   i
 Glowa, Christin [VerfasserIn]   i
 Peschke, Peter [VerfasserIn]   i
 Kraft-Weyrather, Wilma [VerfasserIn]   i
Titel:The RBE in ion beam radiotherapy
Titelzusatz:in vivo studies and clinical application
Verf.angabe:Christian P. Karger, Christin Glowa, Peter Peschke, Wilma Kraft-Weyrather
E-Jahr:2021
Jahr:7 February 2021
Umfang:17 S.
Fussnoten:Version of record 22 May 2021 ; Gesehen am 22.09.2022
Titel Quelle:Enthalten in: Zeitschrift für medizinische Physik
Ort Quelle:Amsterdam [u.a.] : Elsevier, 1990
Jahr Quelle:2021
Band/Heft Quelle:31(2021), 2, Seite 105-121
ISSN Quelle:1876-4436
Abstract:Ion beams used for radiotherapy exhibit an increased relative biological effectiveness (RBE), which depends on several physical treatment parameters as well as on biological factors of the irradiated tissues. While the RBE is an experimentally well-defined quantity, translation to patients is complex and requires radiobiological studies, dedicated models to calculate the RBE in treatment planning as well as strategies for dose prescription. Preclinical in vivo studies and analysis of clinical outcome are important to validate and refine RBE-models. This review describes the concept of the experimental and clinical RBE and explains the fundamental dependencies of the RBE based on in vitro experiments. The available preclinical in vivo studies on normal tissue and tumor RBE for ions heavier than protons are reviewed in the context of the historical and present development of ion beam radiotherapy. In addition, the role of in vivo RBE-values in the development and benchmarking of RBE-models as well as the transition of these models to clinical application are described. Finally, limitations in the translation of experimental RBE-values into clinical application and the direction of future research are discussed.
DOI:doi:10.1016/j.zemedi.2020.12.001
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.zemedi.2020.12.001
 Volltext: https://www.sciencedirect.com/science/article/pii/S0939388920301306
 DOI: https://doi.org/10.1016/j.zemedi.2020.12.001
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Clinical application
 Ion beam radiotherapy
 Preclinical and studies
 RBE validation
 Relative biological effectiveness (RBE)
K10plus-PPN:1817266349
Verknüpfungen:→ Zeitschrift

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