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| Verfasst von: | Ngaimisi, Eliford [VerfasserIn]  |
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| | Mugusi, S. [VerfasserIn] |
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| | Minzi, O. [VerfasserIn] |
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| | Sasi, P. [VerfasserIn] |
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| | Riedel, Klaus-Dieter [VerfasserIn] |
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| | Suda, A. [VerfasserIn] |
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| | Ueda, N. [VerfasserIn] |
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| | Janabi, M. [VerfasserIn] |
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| | Mugusi, F. [VerfasserIn] |
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| | Haefeli, Walter E. [VerfasserIn] |
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| | Bertilsson, L. [VerfasserIn] |
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| | Burhenne, Jürgen [VerfasserIn] |
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| | Aklillu, E. [VerfasserIn] |
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| Titel: | Effect of rifampicin and CYP2B6 genotype on long-term efavirenz autoinduction and plasma exposure in HIV patients with or without tuberculosis |
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| Verf.angabe: | E Ngaimisi, S Mugusi, O Minzi, P Sasi, K-D Riedel, A Suda, N Ueda, M Janabi, F Mugusi, WE Haefeli, L Bertilsson, J Burhenne and E Aklillu |
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| E-Jahr: | 2011 |
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| Jahr: | 03 August 2011 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 22.09.2022 |
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| Titel Quelle: | Enthalten in: Clinical pharmacology & therapeutics |
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| Ort Quelle: | Hoboken, NJ : Wiley-Blackwell, 1960 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 90(2011), 3 vom: Sept., Seite 406-413 |
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| ISSN Quelle: | 1532-6535 |
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| Abstract: | We performed a prospective comparative study to examine, from a pharmacogenetics perspective, the effect of rifampicin (RIF) on long-term efavirenz (EFV) autoinduction and kinetics. In a study population of patients with HIV receiving EFV with RIF (arm 2, n = 54) or without RIF (arm 1, n = 128 controls), intraindividual and interindividual plasma EFV and 8-hydroxyefavirenz levels were compared at weeks 4 and 16 of EFV therapy. In arm 2, RIF was initiated 4 weeks before starting EFV. In controls (arm 1), the plasma EFV was significantly lower whereas 8-hydroxyefavirenz was higher at week 16 as compared to week 4. By contrast, there were no significant differences in plasma EFV and 8-hydroxyefavirenz concentrations over time in arm 2. At week 4, the plasma EFV concentration was significantly lower in arm 2 as compared to arm 1, but no significant differences were observed by week 16. When stratified by CYP2B6 genotype, significant differences were observed only with respect to CYP2B6*1/*1 genotypes. Ours is the first report of the CYP2B6 genotype-dependent effect of RIF on long-term EFV autoinduction. Clinical Pharmacology & Therapeutics (2011) 90 3, 406-413. doi:10.1038/clpt.2011.129 |
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| DOI: | doi:10.1038/clpt.2011.129 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/clpt.2011.129 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1038/clpt.2011.129 |
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| | DOI: https://doi.org/10.1038/clpt.2011.129 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1817283871 |
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| Verknüpfungen: | → Zeitschrift |
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Effect of rifampicin and CYP2B6 genotype on long-term efavirenz autoinduction and plasma exposure in HIV patients with or without tuberculosis / Ngaimisi, Eliford [VerfasserIn]; 03 August 2011 (Online-Ressource)
