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Status: Bibliographieeintrag

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Verfasst von:Nickkholgh, Arash [VerfasserIn]   i
 Schneider, Heinz [VerfasserIn]   i
 Sobirey, Michael [VerfasserIn]   i
 Venetz, Werner P. [VerfasserIn]   i
 Hinz, Ulf [VerfasserIn]   i
 Pelzl, Le H. [VerfasserIn]   i
 Gotthardt, Daniel [VerfasserIn]   i
 Cekauskas, Albertas [VerfasserIn]   i
 Manikas, Martynas [VerfasserIn]   i
 Mikalauskas, Saulius [VerfasserIn]   i
 Mikalauskene, Laura [VerfasserIn]   i
 Bruns, Helge [VerfasserIn]   i
 Zorn, Markus [VerfasserIn]   i
 Weigand, Markus A. [VerfasserIn]   i
 Büchler, Markus W. [VerfasserIn]   i
 Schemmer, Peter [VerfasserIn]   i
Titel:The use of high-dose melatonin in liver resection is safe
Titelzusatz:first clinical experience
Verf.angabe:Arash Nickkholgh, Heinz Schneider, Michael Sobirey, Werner P. Venetz, Ulf Hinz, Le H. Pelzl, Daniel N. Gotthardt, Albertas Cekauskas, Martynas Manikas, Saulius Mikalauskas, Laura Mikalauskene, Helge Bruns, Markus Zorn, Markus A. Weigand, Markus W. Büchler and Peter Schemmer
E-Jahr:2011
Jahr:29 March 2011
Umfang:8 S.
Fussnoten:Gesehen am 22.09.2022
Titel Quelle:Enthalten in: Journal of pineal research
Ort Quelle:Oxford [u.a.] : Wiley-Blackwell, 1984
Jahr Quelle:2011
Band/Heft Quelle:50(2011), 4 vom: Mai, Seite 381-388
ISSN Quelle:1600-079X
Abstract:Abstract: Experimental data suggest that melatonin decreases inflammatory changes after major liver resection, thus positively influencing the postoperative course. To assess the safety of a preoperative single dose of melatonin in patients undergoing major liver resection, a randomized controlled double-blind pilot clinical trial with two parallel study arms was designed at the Department of General and Transplantation Surgery, Ruprecht-Karls-University, Heidelberg. A total of 307 patients, who were referred for liver surgery, were screened. One hundred and thirteen patients, for whom a major liver resection (≥3 segments) was scheduled, were eligible. Sixty-three eligible patients refused to participate, and therefore, 50 patients were randomized. A preoperative single dose of melatonin (50 mg/kg BW) dissolved in 250 mL of milk was administered through the gastric tube after the intubation for general anesthesia. Controls were given the same amount of microcrystalline cellulose. Primary endpoint was safety. Secondary endpoints were postoperative complications. Melatonin was effectively absorbed with serum concentrations of 1142.8 ± 7.2 ng/mL (mean ± S.E.M.) versus 0.3 ± 7.8 ng/mL in controls (P < 0.0001). Melatonin treatment resulted in lower postoperative transaminases over the study period (P = 0.6). There was no serious adverse event in patients after melatonin treatment. A total of three infectious complications occurred in either group. A total of eight noninfectious complications occurred in five control patients, whereas three noninfectious complications occurred in three patients receiving preoperative melatonin (P = 0.3). There was a trend toward shorter ICU stay and total hospital stay after melatonin treatment. Therefore, a single preoperative enteral dose of melatonin is effectively absorbed and is safe and well tolerated in patients undergoing major liver surgery.
DOI:doi:10.1111/j.1600-079X.2011.00854.x
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1111/j.1600-079X.2011.00854.x
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-079X.2011.00854.x
 DOI: https://doi.org/10.1111/j.1600-079X.2011.00854.x
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:antioxidant
 liver resection
 melatonin
 warm ischemia
K10plus-PPN:1817301624
Verknüpfungen:→ Zeitschrift

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