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Status: Bibliographieeintrag

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Verfasst von:Jarrell, Justin A. [VerfasserIn]   i
 Baker, Matthew C. [VerfasserIn]   i
 Perugino, Cory A. [VerfasserIn]   i
 Liu, Hang [VerfasserIn]   i
 Bloom, Michelle S. [VerfasserIn]   i
 Maehara, Takashi [VerfasserIn]   i
 Wong, Heidi H. [VerfasserIn]   i
 Lanz, Tobias [VerfasserIn]   i
 Adamska, Julia Z. [VerfasserIn]   i
 Kongpachith, Sarah [VerfasserIn]   i
 Sokolove, Jeremy [VerfasserIn]   i
 Stone, John H. [VerfasserIn]   i
 Pillai, Shiv S. [VerfasserIn]   i
 Robinson, William H. [VerfasserIn]   i
Titel:Neutralizing anti-IL-1 receptor antagonist autoantibodies induce inflammatory and fibrotic mediators in IgG4-related disease
Verf.angabe:Justin A. Jarrell, PhD, Matthew C. Baker, MD, MS, Cory A. Perugino, DO, Hang Liu, MD, Michelle S. Bloom, PhD, Takashi Maehara, DS, PhD, Heidi H. Wong, BS, Tobias V. Lanz, MD, Julia Z. Adamska, BA, Sarah Kongpachith, Ph.D, Jeremy Sokolove, MD, John H. Stone, MD, MPH, Shiv S. Pillai, MBBS, PhD, and William H. Robinson, MD, PhD
Jahr:2022
Umfang:11 S.
Fussnoten:Online verfügbar May 8, 2021 ; Gesehen am 23.09.2022
Titel Quelle:Enthalten in: The journal of allergy and clinical immunology
Ort Quelle:Amsterdam [u.a.] : Elsevier, 1971
Jahr Quelle:2022
Band/Heft Quelle:149(2022), 1 vom: Jan., Seite 358-368
ISSN Quelle:1097-6825
Abstract:Background - IgG4-related disease (IgG4-RD) is a fibroinflammatory condition involving loss of B-cell tolerance and production of autoantibodies. However, the relevant targets and role of these aberrant humoral immune responses are not defined. - Objective - Our aim was to identify novel autoantibodies and autoantigen targets that promote pathogenic responses in IgG4-RD. - Methods - We sequenced plasmablast antibody repertoires in patients with IgG4-RD. Representative mAbs were expressed and their specificities characterized by using cytokine microarrays. The role of anti-IL-1 receptor antagonist (IL-1RA) autoantibodies was investigated by using in vitro assays. - Results - We identified strong reactivity against human IL-1RA by using a clonally expanded plasmablast-derived mAb from a patient with IgG4-RD. Plasma from patients with IgG4-RD exhibited elevated levels of reactivity against IL-1RA compared with plasma from the controls and neutralized IL-1RA activity, resulting in inflammatory and fibrotic mediator production in vitro. IL-1RA was detected in lesional tissues from patients with IgG4-RD. Patients with anti-IL-1RA autoantibodies of the IgG4 subclass had greater numbers of organs affected than did those without anti-IL-1RA autoantibodies. Peptide analyses identified IL-1RA epitopes targeted by anti-IL-1RA antibodies at sites near the IL-1RA/IL-1R interface. Serum from patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) also had elevated levels of anti-IL-1RA autoantibodies compared with those of the controls. - Conclusion - A subset of patients with IgG4-RD have anti-IL-1RA autoantibodies, which promote proinflammatory and profibrotic meditator production via IL-1RA neutralization. These findings support a novel immunologic mechanism underlying the pathogenesis of IgG4-RD. Anti-IL-1RA autoantibodies are also present in a subset of patients with SLE and RA, suggesting a potential common pathway in multiple autoimmune diseases.
DOI:doi:10.1016/j.jaci.2021.05.002
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.jaci.2021.05.002
 Volltext: https://www.sciencedirect.com/science/article/pii/S0091674921007296
 DOI: https://doi.org/10.1016/j.jaci.2021.05.002
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:autoantibodies
 autoimmune disease
 cytokine
 IgG4-related disease
 IL-1 receptor antagonist
 lupus
 plasmablast
 rheumatoid arthritis
 sequencing
K10plus-PPN:1817318616
Verknüpfungen:→ Zeitschrift

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