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| Verfasst von: | Łabuz, Grzegorz [VerfasserIn]  |
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| | Zielińska, Agnieszka [VerfasserIn] |
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| | Kessler, Lucy Joanne [VerfasserIn] |
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| | Rayamajhi, Asu [VerfasserIn] |
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| | Komar, Katarzyna [VerfasserIn] |
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| | Khoramnia, Ramin [VerfasserIn] |
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| | Auffarth, Gerd U. [VerfasserIn] |
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| Titel: | Two-photon vision in age-related macular degeneration |
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| Titelzusatz: | a translational study |
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| Verf.angabe: | Grzegorz Łabuz, Agnieszka Zielińska, Lucy J. Kessler, Asu Rayamajhi, Katarzyna Komar, Ramin Khoramnia and Gerd U. Auffarth |
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| E-Jahr: | 2022 |
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| Jahr: | 21 March 2022 |
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| Umfang: | 12 S. |
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| Fussnoten: | Published: 21 March 2022 ; Gesehen am 26.09.2022 |
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| Titel Quelle: | Enthalten in: Diagnostics |
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| Ort Quelle: | Basel : MDPI, 2011 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 12(2022), 3, Artikel-ID 760, Seite 1-12 |
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| ISSN Quelle: | 2075-4418 |
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| Abstract: | The recently introduced term “two-photon vision” relates to the visual perception resulting from a simultaneous absorption of two photons by photoreceptors. In this study, we determined two-photon retinal sensitivity in age-related macular degeneration (AMD) and compared it that in normal aging. Microperimetry was performed with visible (white) light and infrared (IR) light, which was perceived as green in the two-photon stimulation. In total, 45 subjects were included with one (better) eye studied. Furthermore, best-corrected visual acuity (VA) and ocular straylight were assessed. AMD resulted in decreased median (interquartile range) logMAR VA, i.e., 0.15 (0.05; 0.24), which in normal eyes was −0.02 (−0.06; 0.02). The two groups showed comparable straylight levels. Sensitivity to IR light was significantly lower in the AMD group (p < 0.001): 8.3 (7.4, 9.3) dB than in controls 10.7 (9.7, 11.2) dB. AMD also significantly affected visible light sensitivity (p < 0.001): 14.0 (11.0; 15.5) dB vs. 18.0 (16.3; 18.9) dB. Notably, the two-photon approach yielded a lower data spread. In conclusion, AMD considerably impairs retinal sensitivity measured in the single- and two-photon realm. However, two-photon-vision microperimetry may improve the testing accuracy and offer an additional diagnostic parameter (beyond VA measurements) for retinal function assessment. |
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| DOI: | doi:10.3390/diagnostics12030760 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/diagnostics12030760 |
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| | Volltext: https://www.mdpi.com/2075-4418/12/3/760 |
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| | DOI: https://doi.org/10.3390/diagnostics12030760 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | AMD |
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| | microperimetry |
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| | normal aging |
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| | retinal sensitivity |
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| | two-photon vision |
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| K10plus-PPN: | 1817436139 |
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| Verknüpfungen: | → Zeitschrift |
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Two-photon vision in age-related macular degeneration / Łabuz, Grzegorz [VerfasserIn]; 21 March 2022 (Online-Ressource)
