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| Verfasst von: | Fritsche, Andreas [VerfasserIn]  |
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| | Wagner, Robert [VerfasserIn] |
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| | Heni, Martin [VerfasserIn] |
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| | Kantartzis, Kostantinos [VerfasserIn] |
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| | Machann, Jürgen [VerfasserIn] |
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| | Schick, Fritz [VerfasserIn] |
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| | Lehmann, Rainer [VerfasserIn] |
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| | Peter, Andreas [VerfasserIn] |
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| | Dannecker, Corinna [VerfasserIn] |
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| | Fritsche, Louise [VerfasserIn] |
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| | Valenta, Vera [VerfasserIn] |
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| | Schick, Renate [VerfasserIn] |
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| | Nawroth, Peter Paul [VerfasserIn] |
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| | Kopf, Stefan [VerfasserIn] |
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| | Pfeiffer, Andreas F.H. [VerfasserIn] |
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| | Kabisch, Stefan [VerfasserIn] |
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| | Dambeck, Ulrike [VerfasserIn] |
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| | Stumvoll, Michael [VerfasserIn] |
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| | Blüher, Matthias [VerfasserIn] |
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| | Birkenfeld, Andreas L. [VerfasserIn] |
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| | Schwarz, Peter [VerfasserIn] |
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| | Hauner, Hans [VerfasserIn] |
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| | Clavel, Julia [VerfasserIn] |
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| | Seißler, Jochen [VerfasserIn] |
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| | Lechner, Andreas [VerfasserIn] |
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| | Müssig, Karsten [VerfasserIn] |
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| | Weber, Katharina [VerfasserIn] |
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| | Laxy, Michael [VerfasserIn] |
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| | Bornstein, Stefan [VerfasserIn] |
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| | Schürmann, Annette [VerfasserIn] |
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| | Roden, Michael [VerfasserIn] |
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| | de Angelis, Martin Hrabe [VerfasserIn] |
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| | Stefan, Norbert [VerfasserIn] |
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| | Häring, Hans-Ulrich [VerfasserIn] |
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| Titel: | Different effects of lifestyle intervention in high- and low-risk prediabetes |
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| Titelzusatz: | results of the randomized controlled Prediabetes Lifestyle Intervention Study (PLIS) |
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| Verf.angabe: | Andreas Fritsche, Robert Wagner, Martin Heni, Kostantinos Kantartzis, Jürgen Machann, Fritz Schick, Rainer Lehmann, Andreas Peter, Corinna Dannecker, Louise Fritsche, Vera Valenta, Renate Schick, Peter Paul Nawroth, Stefan Kopf, Andreas F.H. Pfeiffer, Stefan Kabisch, Ulrike Dambeck, Michael Stumvoll, Matthias Blüher, Andreas L. Birkenfeld, Peter Schwarz, Hans Hauner, Julia Clavel, Jochen Seißler, Andreas Lechner, Karsten Müssig, Katharina Weber, Michael Laxy, Stefan Bornstein, Annette Schürmann, Michael Roden, Martin Hrabe de Angelis, Norbert Stefan, and Hans-Ulrich Häring |
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| E-Jahr: | 2021 |
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| Jahr: | September 16 2021 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 27.09.2022 |
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| Titel Quelle: | Enthalten in: Diabetes |
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| Ort Quelle: | Alexandria, Va : Assoc., 1952 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 70(2021), 12 vom: Dez., Seite 2785-2795 |
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| ISSN Quelle: | 1939-327X |
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| Abstract: | Lifestyle intervention (LI) can prevent type 2 diabetes, but response to LI varies depending on risk subphenotypes. We tested whether individuals with prediabetes with low risk (LR) benefit from conventional LI and individuals with high risk (HR) benefit from an intensification of LI in a multicenter randomized controlled intervention over 12 months with 2 years’ follow-up. A total of 1,105 individuals with prediabetes based on American Diabetes Association glucose criteria were stratified into an HR or LR phenotype based on previously described thresholds of insulin secretion, insulin sensitivity, and liver fat content. LR individuals were randomly assigned to conventional LI according to the Diabetes Prevention Program (DPP) protocol or control (1:1) and HR individuals to conventional or intensified LI with doubling of required exercise (1:1). A total of 908 (82%) participants completed the study. In HR individuals, the difference between conventional and intensified LI in postchallenge glucose change was −0.29 mmol/L [95% CI −0.54; −0.04], P = 0.025. Liver fat (−1.34 percentage points [95% CI −2.17; −0.50], P = 0.002) and cardiovascular risk (−1.82 percentage points [95% CI −3.13; −0.50], P = 0.007) underwent larger reductions with intensified than with conventional LI. During a follow-up of 3 years, intensified compared with conventional LI had a higher probability of normalizing glucose tolerance (P = 0.008). In conclusion, it is possible in HR individuals with prediabetes to improve glycemic and cardiometabolic outcomes by intensification of LI. Individualized, risk phenotype-based LI may be beneficial for the prevention of diabetes. |
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| DOI: | doi:10.2337/db21-0526 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.2337/db21-0526 |
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| | DOI: https://doi.org/10.2337/db21-0526 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1817555898 |
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| Verknüpfungen: | → Zeitschrift |
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Different effects of lifestyle intervention in high- and low-risk prediabetes / Fritsche, Andreas [VerfasserIn]; September 16 2021 (Online-Ressource)
