Centromere regulation

• Verfasst von: Pauleau, Anne-Laure [VerfasserIn]
• Verfasst von: Erhardt, Sylvia [VerfasserIn]
• Titel: Centromere regulation
• Titelzusatz: new players, new rules, new questions
• Verf.angabe: Anne-Laure Pauleau, Sylvia Erhardt
• E-Jahr: 2011
• Jahr: 20 June 2011
• Umfang: 6 S.
• Fussnoten: Gesehen am 28.09.2022
• Titel Quelle: Enthalten in: European journal of cell biology
• Ort Quelle: München : Elsevier, 1998
• Jahr Quelle: 2011
• Band/Heft Quelle: 90(2011), 10, Seite 805-810
• ISSN Quelle: 1618-1298
• DOI: doi:10.1016/j.ejcb.2011.04.016
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Animals
• Sach-SW: Centromere
• Sach-SW: Centromere Protein A
• Sach-SW: Chromatin
• Sach-SW: Chromosomal Proteins, Non-Histone
• Sach-SW: DNA-Binding Proteins
• Sach-SW: Drosophila Proteins
• Sach-SW: Epigenesis, Genetic
• Sach-SW: Gene Expression
• Sach-SW: Heredity
• Sach-SW: Histones
• Sach-SW: Humans
• Sach-SW: Mitosis
• K10plus-PPN: 1817719963

Abstract

Centromeres support the assembly of the kinetochore on every chromosome and are therefore essential for the proper segregation of sister chromatids during cell division. Centromere identity is regulated epigenetically through the presence of the histone H3 variant CENP-A. CENP-A regulation and incorporation specifically into centromeric nucleosomes are the matter of intensive studies in many different model organisms. Here we briefly review the current knowledge in centromere biology with a focus on Drosophila melanogaster and how these insights lead to new rules and challenges.