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| Verfasst von: | Paulsen, Malte [VerfasserIn]  |
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| | Legewie, Stefan [VerfasserIn] |
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| | Eils, Roland [VerfasserIn] |
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| | Karaulanov, Emil [VerfasserIn] |
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| | Niehrs, Christof [VerfasserIn] |
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| Titel: | Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development |
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| Verf.angabe: | Malte Paulsen, Stefan Legewie, Roland Eils, Emil Karaulanov, and Christof Niehrs |
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| E-Jahr: | 2011 |
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| Jahr: | 01 June, 2011 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 29.09.2022 |
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| Titel Quelle: | Enthalten in: National Academy of Sciences (Washington, DC)Proceedings of the National Academy of Sciences of the United States of America |
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| Ort Quelle: | Washington, DC : National Acad. of Sciences, 1915 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 108(2011), 25, Seite 10202-10207 |
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| ISSN Quelle: | 1091-6490 |
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| Abstract: | What makes embryogenesis a robust and canalized process is an important question in developmental biology. A bone morphogenetic protein (BMP) morphogen gradient plays a key role in embryonic development, and we are beginning to understand how the self-regulating properties of its signaling circuitry ensure robust embryonic patterning. An unexplored question is why the BMP signaling circuit is organized as a modular synexpression group, with a prevalence of feedback inhibitors. Here, we provide evidence from direct experimentation and mathematical modeling that the synexpressed feedback inhibitors BAMBI, SMAD6, and SMAD7 (i) expand the dynamic BMP signaling range essential for proper embryonic patterning and (ii) reduce interindividual phenotypic and molecular variability in Xenopus embryos. Thereby, negative feedback linearizes signaling responses and confers robust patterning, thus promoting canalized development. The presence of negative feedback inhibitors in other growth factor synexpression groups suggests that these properties may constitute a general principle. |
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| DOI: | doi:10.1073/pnas.1100179108 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1073/pnas.1100179108 |
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| | DOI: https://doi.org/10.1073/pnas.1100179108 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | Body Patterning |
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| | Bone Morphogenetic Protein 4 |
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| | Feedback, Physiological |
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| | Gene Expression Regulation, Developmental |
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| | Genes, Reporter |
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| | HEK293 Cells |
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| | Humans |
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| | Membrane Proteins |
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| | Models, Theoretical |
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| | Signal Transduction |
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| | Smad6 Protein |
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| | Smad7 Protein |
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| | Xenopus laevis |
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| | Xenopus Proteins |
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| K10plus-PPN: | 1817807544 |
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| Verknüpfungen: | → Zeitschrift |
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Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development / Paulsen, Malte [VerfasserIn]; 01 June, 2011 (Online-Ressource)
