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Verfasst von:Vergunst, Clarissa [VerfasserIn]   i
 van Gurp, Eveline [VerfasserIn]   i
 Hagen, E. Christiaan [VerfasserIn]   i
 van Houwelingen, Hans C. [VerfasserIn]   i
 Hauer, Herbert A. [VerfasserIn]   i
 Noël, Laure-Hélène [VerfasserIn]   i
 Waldherr, Rüdiger [VerfasserIn]   i
 Ferrario, Franco [VerfasserIn]   i
 Woude, Fokko J. van der [VerfasserIn]   i
 Bruijn, Jan A. [VerfasserIn]   i
 Bajema, Ingeborg M. [VerfasserIn]   i
Titel:An index for renal outcome in ANCA-associated glomerulonephritis
Verf.angabe:Clarissa E. Vergunst, Eveline van Gurp, E. Christiaan Hagen, Hans C. van Houwelingen, Herbert A. Hauer, Laure-Hélène Noël, Rüdiger Waldherr, Franco Ferrario, Fokko J. van der Woude, Jan A. Bruijn and Ingeborg M. Bajema, for the EC/BCR Project for ANCA-Assay Standardisation
Jahr:2003
Umfang:7 S.
Fussnoten:Elektronische Reproduktion der Druckausgabe, 21 February 2008 ; Gesehen am 30.09.2022
Titel Quelle:Enthalten in: American journal of kidney diseases
Ort Quelle:Philadelphia, Pa. : Elsevier Saunders, 1981
Jahr Quelle:2003
Band/Heft Quelle:41(2003), 3, Seite 532-538
ISSN Quelle:1523-6838
Abstract:BACKGROUND: The aim of this study is to analyze the predictive value of clinical, serological, and histological parameters for renal outcome in antineutrophil cytoplasmic autoantibody (ANCA)-associated glomerulonephritis by multivariate analysis and create an index valid for clinical use. METHODS: Data from 160 patients with Wegener's granulomatosis, microscopic polyangiitis, and idiopathic rapidly progressive glomerulonephritis without immune deposits (renal-limited vasculitis) were collected. The Cockcroft formula was used to assess renal function expressed by glomerular filtration rate (GFR) at the time of renal biopsy (t = 0) and 1 year later (t = 1). Other clinical parameters were age, sex, and diagnosis. ANCA test results were scored as cytoplasmic ANCA/antiproteinase 3 (anti-PR3) or perinuclear ANCA/antimyeloperoxidase (anti-MPO) positive or negative. Histological data included normal glomeruli, fibrinoid necrosis, extracapillary proliferation, granulomas, interstitial edema, focal and diffuse infiltrates, fibrosis, tubular cylinders/casts, tubular atrophy, tubular necrosis, sclerosis, mesangial proliferation, mesangial matrix expansion, arteriosclerosis, and infiltrates in arterioles. In a separate analysis, we explored whether there were histological differences between patients with anti-PR3 and anti-MPO ANCA test results. RESULTS: Forty percent of the variation in renal function at the time of biopsy can be explained by the presence or absence of tubular atrophy, normal glomeruli, fibrinoid necrosis, extracapillary proliferation, and age. Renal function at the time of biopsy is the best predictor for renal function at t = 1 in patients with ANCA-associated glomerulonephritis. Together with normal glomeruli, fibrinoid necrosis, and age, it explains more than 60% of the variation in GFR at t = 1. ANCA subtype has no independent contribution in predicting patient prognosis. Results translated into a clinically relevant index: GFR at t = 1 = 36.96 + 0.65* (GFR at t = 0) + 10.52 (if normal glomeruli present) + 7.72 (if fibrinoid necrosis present) - 0.42* (age). CONCLUSION: The index created with results from this study provides an indication of renal outcome in patients diagnosed with ANCA-associated glomerulonephritis.
DOI:doi:10.1053/ajkd.2003.50115
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1053/ajkd.2003.50115
 Volltext: https://www.sciencedirect.com/science/article/pii/S0272638602692224
 DOI: https://doi.org/10.1053/ajkd.2003.50115
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Kidney Diseases
 Male
 Humans
 Kidney
 Antibodies, Antineutrophil Cytoplasmic
 Female
 Glomerulonephritis
 Granulomatosis with Polyangiitis
 Vasculitis
 Glomerular Filtration Rate
 Age Factors
 Churg-Strauss Syndrome
 Europe
 Multivariate Analysis
 Predictive Value of Tests
 Prospective Studies
 Retrospective Studies
 Severity of Illness Index
 Sex Distribution
K10plus-PPN:1817890514
Verknüpfungen:→ Zeitschrift

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