| |  Online-Ressource |
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| Verfasst von: | Saenger, Amy [VerfasserIn]  |
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| | Beyrau, R. [VerfasserIn] |
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| | Braun, S. [VerfasserIn] |
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| | Cooray, R. [VerfasserIn] |
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| | Dolci, A. [VerfasserIn] |
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| | Freidank, H. [VerfasserIn] |
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| | Giannitsis, Evangelos [VerfasserIn] |
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| | Gustafson, S. [VerfasserIn] |
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| | Handy, B. [VerfasserIn] |
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| | Katus, Hugo [VerfasserIn] |
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| | Melanson, S. E. [VerfasserIn] |
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| | Panteghini, M. [VerfasserIn] |
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| | Venge, P. [VerfasserIn] |
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| | Zorn, Markus [VerfasserIn] |
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| | Jarolim, P. [VerfasserIn] |
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| | Bruton, D. [VerfasserIn] |
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| | Jarausch, J. [VerfasserIn] |
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| | Jaffe, A. S. [VerfasserIn] |
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| Titel: | Multicenter analytical evaluation of a high-sensitivity troponin T assay |
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| Verf.angabe: | A.K. Saenger, R. Beyrau, S. Braun, R. Cooray, A. Dolci, H. Freidank, E. Giannitsis, S. Gustafson, B. Handy, H. Katus, S.E. Melanson, M. Panteghini, P. Venge, M. Zorn, P. Jarolim, D. Bruton, J. Jarausch, A.S. Jaffe |
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| E-Jahr: | 2011 |
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| Jahr: | 8 January 2011 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 30.09.2022 |
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| Titel Quelle: | Enthalten in: Clinica chimica acta |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1956 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 412(2011), 9, Seite 748-754 |
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| ISSN Quelle: | 1873-3492 |
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| Abstract: | Background - High-sensitivity cardiac troponin assays are being introduced clinically for earlier diagnosis of acute myocardial infarction (AMI). We evaluated the analytical performance of a high-sensitivity cardiac troponin T assay (hscTnT, Roche Diagnostics) in a multicenter, international trial. - Methods - Three US and 5 European sites evaluated hscTnT on the Modular® Analytics E170, cobas® 6000, Elecsys 2010, and cobas® e 411. Precision, accuracy, reportable range, an inter-laboratory comparison trial, and the 99th percentile of a reference population were assessed. - Results - Total imprecision (CVs) were 4.6-36.8% between 3.4 and 10.3ng/L hscTnT. Assay linearity was up to 10,000ng/L and the limit of blank and detection were 3 and 5ng/L, respectively. The 99th percentile reference limit was 14.2ng/L (n=533). No significant differences between specimen types, assay incubation time, or reagent lots existed. A substantial positive bias (76%) exists between the 4th generation and hscTnT assays at the low end of the measuring range (<50ng/L). hscTnT serum pool concentrations were within 2SD limits of the mean of means in the comparison trial, indicating comparable results across multiple platforms and laboratories. - Conclusion - The Roche hscTnT assay conforms to guideline precision requirements and will likely identify additional patients with myocardial injury suspicious for AMI. |
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| DOI: | doi:10.1016/j.cca.2010.12.034 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.cca.2010.12.034 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0009898111000052 |
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| | DOI: https://doi.org/10.1016/j.cca.2010.12.034 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | 99th percentile |
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| | Acute myocardial infarction |
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| | Cardiac biomarkers |
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| | High-sensitivity |
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| | Troponin |
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| K10plus-PPN: | 1817897411 |
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| Verknüpfungen: | → Zeitschrift |
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Multicenter analytical evaluation of a high-sensitivity troponin T assay / Saenger, Amy [VerfasserIn]; 8 January 2011 (Online-Ressource)
