Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease

• Verfasst von: Salkovic-Petrisic, Melita [VerfasserIn]
• Verfasst von: Osmanovic-Barilar, Jelena [VerfasserIn]
• Verfasst von: Brückner, Martina K. [VerfasserIn]
• Verfasst von: Hoyer, Siegfried [VerfasserIn]
• Verfasst von: Arendt, Thomas [VerfasserIn]
• Verfasst von: Riederer, Peter [VerfasserIn]
• Titel: Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease
• Titelzusatz: a long-term follow up study
• Verf.angabe: Melita Salkovic-Petrisic, Jelena Osmanovic-Barilar, Martina K. Brückner, Siegfried Hoyer, Thomas Arendt, Peter Riederer
• E-Jahr: 2011
• Jahr: 30 April 2011
• Umfang: 8 S.
• Fussnoten: Gesehen am 04.10.2022
• Titel Quelle: Enthalten in: Journal of neural transmission
• Ort Quelle: Wien [u.a.] : Springer, 1950
• Jahr Quelle: 2011
• Band/Heft Quelle: 118(2011), 5, Seite 765-772
• ISSN Quelle: 1435-1463
• DOI: doi:10.1007/s00702-011-0651-4
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Erscheint auch als : Druck-Ausgabe: Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease. - 2011
• Sach-SW: Amyloid β
• Sach-SW: Cerebral amyloid angiopathy
• Sach-SW: Intracerebroventricular
• Sach-SW: Streptozotocin
• K10plus-PPN: 1817966278

Abstract

Cerebral amyloid angiopathy is manifested as accumulation of amyloid β (Aβ) peptide in the wall of meningeal and cerebral arteries, arterioles and capillaries and is frequently found postmortem in sporadic Alzheimer’s disease (sAD) patients. It is difficult to assess when and how cerebral amyloid angiopathy develops and progresses in humans in vivo, which is why animal AD models are used. Streptozotocin-intracerebroventricularly (STZ-icv) treated rats have been recently proposed as the model of sAD which develops insulin resistant brain state preceding Aβ pathology development. Vascular Aβ deposits in the brain of STZ-icv-treated rats (3 months old at the time of icv treatment) were visualized by Thioflavine-S staining, Congo red staining and Aβ immunohistochemistry. Thioflavine-S and Congo red staining revealed diffuse congophilic deposits in the wall of meningeal and cortical blood vessels both 6 and 9 months after the STZ-icv treatment. Preliminary Aβ1-42 and Aβ1-16 immunohistochemistry experiments showed positive staining in blood vessels 3 and 9 months after the STZ-icv treatment, respectively. Results suggest that cerebral amyloid angiopathy observed 6 and 9 months after the STZ-icv treatment seems to be a continuation and progression of the amyloid pathology observed already 3 months following the STZ-icv treatment in this non-transgenic sAD animal model.