| |  Online-Ressource |
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| Verfasst von: | Lonardo, Enza [VerfasserIn]  |
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| | Hermann, Patrick C. [VerfasserIn] |
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| | Müller, Maria-Theresa [VerfasserIn] |
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| | Huber, Stephan [VerfasserIn] |
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| | Balic, Anamaria [VerfasserIn] |
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| | Miranda-Lorenzo, Irene [VerfasserIn] |
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| | Zagorac, Sladjana [VerfasserIn] |
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| | Alcala, Sonia [VerfasserIn] |
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| | Rodriguez-Arabaolaza, Iker [VerfasserIn] |
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| | Ramirez, Juan Carlos [VerfasserIn] |
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| | Torres-Ruíz, Raul [VerfasserIn] |
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| | Garcia, Elena [VerfasserIn] |
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| | Hidalgo, Manuel [VerfasserIn] |
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| | Cebrián, David Álvaro [VerfasserIn] |
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| | Heuchel, Rainer [VerfasserIn] |
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| | Löhr, Matthias [VerfasserIn] |
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| | Berger, Frank [VerfasserIn] |
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| | Bartenstein, Peter [VerfasserIn] |
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| | Aicher, Alexandra [VerfasserIn] |
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| | Heeschen, Christopher [VerfasserIn] |
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| Titel: | Nodal/activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy |
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| Verf.angabe: | Enza Lonardo, Patrick C. Hermann, Maria-Theresa Mueller, Stephan Huber, Anamaria Balic, Irene Miranda-Lorenzo, Sladjana Zagorac, Sonia Alcala, Iker Rodriguez-Arabaolaza, Juan Carlos Ramirez, Raul Torres-Ruíz, Elena Garcia, Manuel Hidalgo, David Álvaro Cebrián, Rainer Heuchel, Matthias Löhr, Frank Berger, Peter Bartenstein, Alexandra Aicher, and Christopher Heeschen |
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| E-Jahr: | 2011 |
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| Jahr: | November 4, 2011 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 06.10.2022 |
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| Titel Quelle: | Enthalten in: Cell stem cell |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2007 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 9(2011), 5, Seite 433-446 |
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| ISSN Quelle: | 1875-9777 |
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| Abstract: | Nodal and Activin belong to the TGF-β superfamily and are important regulators of embryonic stem cell fate. Here we investigated whether Nodal and Activin regulate self-renewal of pancreatic cancer stem cells. Nodal and Activin were hardly detectable in more differentiated pancreatic cancer cells, while cancer stem cells and stroma-derived pancreatic stellate cells markedly overexpressed Nodal and Activin, but not TGF-β. Knockdown or pharmacological inhibition of the Nodal/Activin receptor Alk4/7 in cancer stem cells virtually abrogated their self-renewal capacity and in vivo tumorigenicity, and reversed the resistance of orthotopically engrafted cancer stem cells to gemcitabine. However, engrafted primary human pancreatic cancer tissue with a substantial stroma showed no response due to limited drug delivery. The addition of a stroma-targeting hedgehog pathway inhibitor enhanced delivery of the Nodal/Activin inhibitor and translated into long-term, progression-free survival. Therefore, inhibition of the Alk4/7 pathway, if combined with hedgehog pathway inhibition and gemcitabine, provides a therapeutic strategy for targeting cancer stem cells. |
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| DOI: | doi:10.1016/j.stem.2011.10.001 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.stem.2011.10.001 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1934590911004814 |
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| | DOI: https://doi.org/10.1016/j.stem.2011.10.001 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1818139413 |
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| Verknüpfungen: | → Zeitschrift |
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Nodal/activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy / Lonardo, Enza [VerfasserIn]; November 4, 2011 (Online-Ressource)
