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| Verfasst von: | Herpel, Esther [VerfasserIn]  |
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| | Jensen, Katrin [VerfasserIn] |
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| | Muley, Thomas [VerfasserIn] |
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| | Warth, Arne [VerfasserIn] |
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| | Schnabel, Philipp Albert [VerfasserIn] |
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| | Meister, Michael [VerfasserIn] |
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| | Herth, Felix [VerfasserIn] |
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| | Dienemann, Hendrik [VerfasserIn] |
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| | Thomas, Michael [VerfasserIn] |
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| | Gottschling, Sandra [VerfasserIn] |
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| Titel: | The cancer stem cell antigens CD133, BCRP1/ABCG2 and CD117/c-KIT are not associated with prognosis in resected early-stage non-small cell lung cancer |
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| Verf.angabe: | Esther Herpel, Katrin Jensen, Thomas Muley, Arne Warth, Philipp A. Schnabel, Michael Meister, Felix J. F. Herth, Hendrik Dienemann, Michael Thomas and Sandra Gottschling |
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| E-Jahr: | 2011 |
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| Jahr: | [December 2011] |
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| Umfang: | 10 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 06.10.2022 |
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| Titel Quelle: | Enthalten in: Anticancer research |
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| Ort Quelle: | Attiki : [Verlag nicht ermittelbar], 2004 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 31(2011), 12 vom: Dez., Seite 4491-4500 |
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| ISSN Quelle: | 1791-7530 |
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| Abstract: | Background: In various tumor entities, expression of cancer stem cell (CSC) antigens has been proven to be prognostically unfavorable. However, for lung cancer, the data are scant and conflicting. Patients and Methods: The CSC antigens CD117/c-KIT, CD133 and breast cancer resistance protein-1 (BCRP1/ABCG2) were immunohistochemically analyzed in tissues from a total of 133 completely resected stage I/II non-small cell lung cancer (NSCLC) patients with a median follow-up time of 53.8 months. Their expression was related to clinicopathological characteristics, angiogenic features and prognosis. Results: Cox proportional hazards regression analysis revealed no association between CSC antigens, disease-free survival or overall survival (OS). However, in the subgroup of patients with relapse and tumors >3 cm, there was a trend towards worse OS upon expression of CD117 (hazard ratio=2.6, 95%, confidence interval=0.8-8.3, p=0.080). Except for CD133, which was overrepresented in T1 tumors (p=0.001), the CSC antigens were not linked to clinico-pathological characteristics or angiogenic features. Conclusion: In resected early-stage NSCLC, CSC antigens show no association with prognosis. However, in patients with relapse and tumors >3 cm, expression of CD117 might predict worse OS. |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://ar.iiarjournals.org/content/31/12/4491 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Erscheint auch als : Druck-Ausgabe: The cancer stem cell antigens CD133, BCRP1/ABCG2 and CD117/c-KIT are not associated with prognosis in resected early-stage non-small cell lung cancer. - 2011 |
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| Sach-SW: | BCRP1 |
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| | biomarkers |
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| | cancer stem cell antigens |
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| | CD117 |
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| | CD133 |
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| | Non-small cell lung cancer |
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| | prognosis |
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| | tissue microarrays |
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| K10plus-PPN: | 1818153327 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ cancer stem cell antigens CD133, BCRP1/ABCG2 and CD117/c-KIT are not associated with prognosis in resected early-stage non-small cell lung cancer / Herpel, Esther [VerfasserIn]; [December 2011] (Online-Ressource)
