Attenuation-based characterization of coronary atherosclerotic plaque

• Verfasst von: Henzler, Thomas [VerfasserIn]
• Verfasst von: Porubský, Štefan [VerfasserIn]
• Verfasst von: Kayed, Hany [VerfasserIn]
• Verfasst von: Harder, Nils [VerfasserIn]
• Verfasst von: Kriššák, Radko [VerfasserIn]
• Verfasst von: Meyer, Mathias [VerfasserIn]
• Verfasst von: Süselbeck, Tim [VerfasserIn]
• Verfasst von: Marx, Alexander [VerfasserIn]
• Verfasst von: Michaely, Henrik J. M. [VerfasserIn]
• Verfasst von: Schoepf, U. J. [VerfasserIn]
• Verfasst von: Schönberg, Stefan [VerfasserIn]
• Verfasst von: Fink, Christian [VerfasserIn]
• Titel: Attenuation-based characterization of coronary atherosclerotic plaque
• Titelzusatz: comparison of dual source and dual energy CT with single-source CT and histopathology
• Verf.angabe: Thomas Henzler, Stefan Porubsky, Hany Kayed, Nils Harder, U. Radko Krissak, Mathias Meyer, Tim Sueselbeck, Alexander Marx, Henrik Michaely, U. Joseph Schoepf, Stefan O. Schoenberg, Christian Fink
• E-Jahr: 2011
• Jahr: [October 2011]
• Umfang: 6 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 06.10.2022
• Titel Quelle: Enthalten in: European journal of radiology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1990
• Jahr Quelle: 2011
• Band/Heft Quelle: 80(2011), 1 vom: Okt., Seite 54-59
• ISSN Quelle: 1872-7727
• DOI: doi:10.1016/j.ejrad.2010.07.024
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Atherosclerotic plaque imaging
• Sach-SW: Cross scatter radiation
• Sach-SW: Dual energy CT
• Sach-SW: Dual-source computed tomography
• Sach-SW: Histopathology
• K10plus-PPN: 1818160609

Abstract

Objective - To compare different CT acquisition techniques regarding for attenuation-based characterization of coronary atherosclerotic plaques using histopathology as the standard of reference. - Materials and methods - In a post mortem study 17 human hearts were studied with dual-source CT (DSCT) and dual energy CT (DECT) mode on a DSCT as well as with 16-slice single-source CT (SSCT). At autopsy, atherosclerotic lesions were cut at 5μm sections. Histopathologic classification of the plaques according to the American Heart Association (AHA) criteria was performed by two pathologists. Attenuation values of all plaques were measured in DSCT, DECT and SSCT studies, respectively and classified based on attenuation according to modified AHA criteria. - Results - 58 coronary plaques were identified at autopsy. Regardless of the CT technique only 52/58 plaques were found at CT (sensitivity=89.6%). There was no significant difference between the mean attenuation values of different plaque types between DSCT, DECT, and SSCT: type IV: 11HU/8HU/19HU; type Va: 44HU/45HU/52HU; type Vb: 1088HU/966HU/1079HU). The sensitivity for correct classification varied depending on the plaque type (type II=0%, type III=0%, type IV=43%, type Va=58%, Vb=97%). - Conclusion - Independent of the used acquisition technique, SSCT, DSCT and DECT show similar results for attenuation-based characterization of atherosclerotic coronary plaques.