| Online-Ressource |
Verfasst von: | Feuring, Martin [VerfasserIn]  |
| Christ, M. [VerfasserIn]  |
| Roell, A. [VerfasserIn]  |
| Schueller, P. [VerfasserIn]  |
| Lösel, Ralf M. [VerfasserIn]  |
| Dempfle, Carl-Erik [VerfasserIn]  |
| Schultz, Armin [VerfasserIn]  |
| Wehling, Martin [VerfasserIn]  |
Titel: | Alterations in platelet function during the ovarian cycle |
Verf.angabe: | M. Feuring, M. Christ, A. Roell, P. Schueller, R. Losel, C.E. Dempfle, A. Schultz, M. Wehling |
Jahr: | 2002 |
Umfang: | 5 S. |
Fussnoten: | Gesehen am 11.10.2022 |
Titel Quelle: | Enthalten in: Blood coagulation & fibrinolysis |
Ort Quelle: | Hagerstown, Md. : Lippincott, Williams & Wilkins, 1990 |
Jahr Quelle: | 2002 |
Band/Heft Quelle: | 13(2002), 5, Seite 443-447 |
ISSN Quelle: | 1473-5733 |
Abstract: | Steroid hormones may profoundly influence hemostasis; for example, as discussed for hormone replacement therapy, pregnancy and, being less obvious, for the ovarian cycle. We investigated primary hemostasis parameters using a platelet function analyzer (PFA-100TM) during the follicular and luteal phases in 18 healthy young women without oral contraceptives. During the follicular phase, the mean closure time (CT) was 164.7 ± 56.7 s, and it decreased to 130.2 ± 30.6 s in collagen/epinephrine cartridges in the luteal phase (P = 0.0095). No significant difference could be found for CT values in collagen/adenosine diphosphate cartridges during the follicular phase as compared with the luteal phase (97.2 ± 24.2 s versus 89.6 ± 18.4 s, P = 0.174). Negative correlations between the CT values in collagen/epinephrine cartridges and von Willebrand factor from both phases of the cycle were found (follicular phase:r = −0.53; luteal phase:r = −0.54). Fibrinogen and fibrinogen degradation products were significantly increased in the luteal phase (2.49 ± 0.62 g/l versus 2.05 ± 0.59 g/l and 0.12 ± 014 versus 0.04 ± 0.04, P = 0.02 for both parameters) as compared with the follicular phase. No significant differences could be detected for plasminogen, plasmin-antiplasmin complex, prothrombin fragment 1 + 2 and D-dimer between the groups. This study indicates that platelet function is periodically altered during the ovarian cycle due to the influence of progesterone and estrogen on von Willebrand factor concentrations. |
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Volltext: https://journals.lww.com/bloodcoagulation/Fulltext/2002/07000/Alterations_in_platelet_function_during_the.9.aspx |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1818621789 |
Verknüpfungen: | → Zeitschrift |
Alterations in platelet function during the ovarian cycle / Feuring, Martin [VerfasserIn]; 2002 (Online-Ressource)