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Verfasst von:Christ, Michael [VerfasserIn]   i
 Bauersachs, Johann [VerfasserIn]   i
 Liebetrau, Claudia [VerfasserIn]   i
 Heck, Marina [VerfasserIn]   i
 Günther, Andreas [VerfasserIn]   i
 Wehling, Martin [VerfasserIn]   i
Titel:Glucose increases endothelial-dependent superoxide formation in coronary arteries by NAD(P)H oxidase activation
Titelzusatz:attenuation by the 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor atorvastatin
Verf.angabe:Michael Christ, Johann Bauersachs, Claudia Liebetrau, Marina Heck, Andreas Günther, Martin Wehling
Jahr:2002
Umfang:5 S.
Fussnoten:Gesehen am 12.10.2022
Titel Quelle:Enthalten in: Diabetes
Ort Quelle:Alexandria, Va : Assoc., 1952
Jahr Quelle:2002
Band/Heft Quelle:51(2002), 8, Seite 2648-2652
ISSN Quelle:1939-327X
Abstract:Increased vascular superoxide anion (O2−) formation is essentially involved in the pathophysiology of atherosclerosis. Chronic hyperglycemia induces endothelial dysfunction, probably due to increased formation of reactive oxygen intermediates. However, little is known about the localization, modulators, and molecular mechanisms of vascular O2− formation during hyperglycemia. In porcine coronary segments, high glucose significantly increased O2− formation (1,703.5 ± 394.9 vs. 834.1 ± 91.7 units/mg for control, n = 64, P < 0.05; measured by lucigenin-enhanced chemiluminescence). This effect was completely blocked after removal of the endothelium. Coincubation with 10 μmol/l atorvastatin, a lipophilic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, attenuated basal and glucose-induced O2− formation (328.1 ± 46.5 and 332.8 ± 50.3 units/mg, P < 0.05 vs. without atorvastatin). Incubation with mevalonic acid reversed this effect. High glucose increased mRNA expression of the oxidase subunit p22phox, which was blocked by 10 μmol/l atorvastatin, whereas expression of gp91phox was unchanged. In conclusion, glucose-induced increase of vascular O2− formation is endothelium dependent and is probably mediated by increased p22phox subunit expression. Beneficial effects of statins in diabetic patients may be explained in part by attenuation of vascular O2− formation independent of lipid lowering.
DOI:doi:10.2337/diabetes.51.8.2648
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.2337/diabetes.51.8.2648
 DOI: https://doi.org/10.2337/diabetes.51.8.2648
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1818799766
Verknüpfungen:→ Zeitschrift

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