Calcium signaling in cognition and aging-dependent cognitive decline

• Verfasst von: Oliveira, Ana [VerfasserIn]
• Verfasst von: Bading, Hilmar [VerfasserIn]
• Titel: Calcium signaling in cognition and aging-dependent cognitive decline
• Verf.angabe: Ana MM Oliveira and Hilmar Bading
• E-Jahr: 2011
• Jahr: 22 June 2011
• Umfang: 6 S.
• Fussnoten: Gesehen am 12.10.2022
• Titel Quelle: Enthalten in: Biofactors
• Ort Quelle: Malden, Mass. : Wiley, 1997
• Jahr Quelle: 2011
• Band/Heft Quelle: 37(2011), 3 vom: Mai/Juni, Seite 168-174
• ISSN Quelle: 1872-8081
• DOI: doi:10.1002/biof.148
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: aging
• Sach-SW: calcium
• Sach-SW: cognition
• K10plus-PPN: 181880428X

Abstract

Calcium-dependent signals are key triggers of the molecular mechanisms underlying learning and memory and dysregulation of calcium homeostasis in the aging brain has been proposed to underlie aging-dependent cognitive decline. Mechanisms triggered by calcium in neurons include activity-dependent activation of transcription responsible for the synthesis of molecules underlying the long-term changes of neuronal function. Effectors of calcium signaling with a primordial role in transcription regulation are calcium signal-regulated transcription factors. In this review, we summarize the current knowledge of the contribution of key calcium signal-regulated transcription factors, namely CREB, NFAT, and DREAM, to memory formation. We further describe evidence for dysregulation of the activity of these factors during aging.