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Verfasst von:Şen, Sinan [VerfasserIn]   i
 Erber, Ralf [VerfasserIn]   i
Titel:Neuronal guidance molecules in bone remodeling and orthodontic tooth movement
Verf.angabe:Sinan Şen and Ralf Erber
E-Jahr:2022
Jahr:3 September 2022
Umfang:18 S.
Fussnoten:Gesehen am 17.10.2022
Titel Quelle:Enthalten in: International journal of molecular sciences
Ort Quelle:Basel : Molecular Diversity Preservation International, 2000
Jahr Quelle:2022
Band/Heft Quelle:23(2022), 17, Artikel-ID 10077, Seite 1-18
ISSN Quelle:1422-0067
 1661-6596
Abstract:During orthodontic tooth movement, mechanically induced remodeling occurs in the alveolar bone due to the action of orthodontic forces. The number of factors identified to be involved in mechanically induced bone remodeling is growing steadily. With the uncovering of the functions of neuronal guidance molecules (NGMs) for skeletal development as well as for bone homeostasis, NGMs are now also among the potentially significant factors for the regulation of bone remodeling during orthodontic tooth movement. This narrative review attempts to summarize the functions of NGMs in bone homeostasis and provides insight into the currently sparse literature on the functions of these molecules during orthodontic tooth movement. Presently, four families of NGMs are known: Netrins, Slits, Semaphorins, ephrins and Eph receptors. A search of electronic databases revealed roles in bone homeostasis for representatives from all four NGM families. Functions during orthodontic tooth movement, however, were only identified for Semaphorins, ephrins and Eph receptors. For these, crucial prerequisites for participation in the regulation of orthodontically induced bone remodeling, such as expression in cells of the periodontal ligament and in the alveolar bone, as well as mechanical inducibility, were shown, which suggests that the importance of NGMs in orthodontic tooth movement may be underappreciated to date and further research might be warranted.
DOI:doi:10.3390/ijms231710077
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3390/ijms231710077
 Volltext: https://www.mdpi.com/1422-0067/23/17/10077
 DOI: https://doi.org/10.3390/ijms231710077
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:bone remodeling
 Eph receptors
 ephrins
 neuronal guidance molecules
 orthodontic tooth movement
 Semaphorins
K10plus-PPN:1819006514
Verknüpfungen:→ Zeitschrift

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