Status: Bibliographieeintrag
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| Verfasst von: | Schwab, Constantin [VerfasserIn]  |
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| | Domke, Lisa Maria [VerfasserIn] |
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| | Rose, Fabian [VerfasserIn] |
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| | Haußer-Siller, Ingrid [VerfasserIn] |
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| | Schirmacher, Peter [VerfasserIn] |
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| | Longerich, Thomas [VerfasserIn] |
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| Titel: | Cell tropism and viral clearance during SARS-CoV-2 lung infection |
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| Verf.angabe: | Constantin Schwab, Lisa Maria Domke, Fabian Rose, Ingrid Hausser, Peter Schirmacher, Thomas Longerich |
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| E-Jahr: | 2022 |
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| Jahr: | 30 June 2022 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 17.10.2022 |
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| Titel Quelle: | Enthalten in: Pathology, research and practice |
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| Ort Quelle: | München : Elsevier, 1978 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 236(2022), Artikel-ID 154000, Seite 1-7 |
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| ISSN Quelle: | 1618-0631 |
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| Abstract: | Pulmonary capillary microthrombosis has been proposed as a major pathogenetic factor driving severe COVID-19. Autopsy studies reported endothelialitis but it is under debate if it is caused by SARS-CoV-2 infection of endothelial cells. In this study, RNA in situ hybridization was used to detect viral RNA and to identify the infected cell types in lung tissue of 40 patients with fatal COVID-19. SARS-CoV-2 Spike protein-coding RNA showed a steadily decreasing signal abundance over a period of three weeks. Besides the original virus strain the variants of concern Alpha (B.1.1.7), Delta (B.1.617.2), and Omicron (B.1.1.529) could also be detected by the assay. Viral RNA was mainly detected in alveolar macrophages and pulmonary epithelial cells, while only single virus-positive endothelial cells were observed even in cases with high viral load suggesting that viral infection of endothelial cells is not a key factor for the development of pulmonary capillary microthrombosis. |
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| DOI: | doi:10.1016/j.prp.2022.154000 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.prp.2022.154000 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0344033822002448 |
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| | DOI: https://doi.org/10.1016/j.prp.2022.154000 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cellular target |
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| | COVID-19 |
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| | Endothelialitis |
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| | SARS-CoV-2 infection |
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| | Time-course |
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| K10plus-PPN: | 1819035425 |
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| Verknüpfungen: | → Zeitschrift |
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Cell tropism and viral clearance during SARS-CoV-2 lung infection / Schwab, Constantin [VerfasserIn]; 30 June 2022 (Online-Ressource)
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