| |  Online-Ressource |
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| Verfasst von: | Slof-Op 't Landt, Rita [VerfasserIn]  |
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| | Meulenbelt, I. [VerfasserIn] |
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| | Bartels, M. [VerfasserIn] |
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| | Suchiman, E. [VerfasserIn] |
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| | Middeldorp, C. M. [VerfasserIn] |
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| | Houwing-Duistermaat, J. J. [VerfasserIn] |
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| | van Trier, J. [VerfasserIn] |
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| | Onkenhout, E. J. [VerfasserIn] |
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| | Vink, J. M. [VerfasserIn] |
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| | van Beijsterveldt, C. E. M. [VerfasserIn] |
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| | Brandys, M. K. [VerfasserIn] |
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| | Sanders, N. [VerfasserIn] |
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| | Zipfel, Stephan [VerfasserIn] |
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| | Herzog, Wolfgang [VerfasserIn] |
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| | Herpertz-Dahlmann, Beate [VerfasserIn] |
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| | Klampfl, K. [VerfasserIn] |
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| | Fleischhaker, C. [VerfasserIn] |
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| | Zeeck, A. [VerfasserIn] |
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| | de Zwaan, M. [VerfasserIn] |
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| | Herpertz, Sabine [VerfasserIn] |
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| | Ehrlich, S. [VerfasserIn] |
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| | van Elburg, A. A. [VerfasserIn] |
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| | Adan, R. a. H. [VerfasserIn] |
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| | Scherag, S. [VerfasserIn] |
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| | Hinney, A. [VerfasserIn] |
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| | Hebebrand, J. [VerfasserIn] |
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| | Boomsma, D. I. [VerfasserIn] |
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| | van Furth, E. F. [VerfasserIn] |
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| | Slagboom, P. E. [VerfasserIn] |
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| Titel: | Association study in eating disorders |
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| Titelzusatz: | TPH2 associates with anorexia nervosa and self-induced vomiting |
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| Verf.angabe: | M.C.T. Slof-Op ‘t Landt, I. Meulenbelt, M. Bartels, E. Suchiman, C.M. Middeldorp, J.J. Houwing-Duistermaat, J. van Trier, E.J. Onkenhout, J.M. Vink, C.E.M. van Beijsterveldt, M.K. Brandys, N. Sanders, S. Zipfel, W. Herzog, B. Herpertz-Dahlmann, K. Klampfl, C. Fleischhaker, A. Zeeck, M. de Zwaan, S. Herpertz, S. Ehrlich, A.A. van Elburg, R.a.H. Adan, S. Scherag, A. Hinney, J. Hebebrand, D.I. Boomsma, E.F. van Furth and P.E. Slagboom |
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| Jahr: | 2011 |
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| Umfang: | 8 S. |
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| Fussnoten: | Erstmals veröffentlicht am 14. Oktober 2010 ; Gesehen am 20.10.2022 |
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| Titel Quelle: | Enthalten in: Genes, brain and behavior |
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| Ort Quelle: | Copenhagen [u.a.] : Blackwell Munksgaard, 2002 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 10(2011), 2 vom: März, Seite 236-243 |
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| ISSN Quelle: | 1601-183X |
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| Abstract: | Twin studies suggest that genetic factors play a substantial role in anorexia nervosa (AN) and self-induced vomiting (SV), a key symptom that is shared among different types of eating disorders (EDs). We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of the common variance in candidate genes, stathmin (STMN1), serotonin receptor 1D (HTR1D), tryptophan hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF), with AN and EDs characterized by regular SV. The first allele frequencies of all the SNPs were compared between a Dutch case group (182 AN, 149 EDs characterized by SV) and 607 controls. Associations rendering P-values < 0.05 from this initial study were then tested for replication in a meta-analysis with two additional independent ED case-control samples, together providing 887 AN cases, 306 cases with an ED characterized by SV and 1914 controls. A significant effect for the minor C-allele of tryptophan hydroxylase 2 rs1473473 was observed for both AN [odds ratio (OR) = 1.30, 95% CI 1.08-1.57, P < 0.003] and EDs characterized by SV (OR = 1.52, 95% CI 1.28-2.04, P < 0.006). In the combined case group, a dominant effect was observed for rs1473473 (OR = 1.38, 95% CI 1.16-1.64, P < 0.0003). The meta-analysis revealed that the tryptophan hydroxylase 2 polymorphism rs1473473 was associated with a higher risk for AN, EDs characterized by SV and for the combined group. |
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| DOI: | doi:10.1111/j.1601-183X.2010.00660.x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1111/j.1601-183X.2010.00660.x |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1601-183X.2010.00660.x |
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| | DOI: https://doi.org/10.1111/j.1601-183X.2010.00660.x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Anorexia nervosa |
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| | candidate genes |
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| | genetic association study |
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| | TPH2 self-induced vomiting |
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| K10plus-PPN: | 1819453006 |
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| Verknüpfungen: | → Zeitschrift |
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Association study in eating disorders / Slof-Op 't Landt, Rita [VerfasserIn]; 2011 (Online-Ressource)
