| |  Online-Ressource |
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| Verfasst von: | Fischer, Chiara [VerfasserIn]  |
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| | Turchinovich, Andrey [VerfasserIn] |
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| | Feißt, Manuel [VerfasserIn] |
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| | Riedel, Fabian [VerfasserIn] |
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| | Haßdenteufel, Kathrin [VerfasserIn] |
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| | Scharli, Philipp [VerfasserIn] |
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| | Hartkopf, Andreas [VerfasserIn] |
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| | Brucker, Sara [VerfasserIn] |
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| | Michel, Laura L. [VerfasserIn] |
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| | Burwinkel, Barbara [VerfasserIn] |
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| | Schneeweiss, Andreas [VerfasserIn] |
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| | Wallwiener, Markus [VerfasserIn] |
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| | Deutsch, Thomas M. [VerfasserIn] |
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| Titel: | Circulating miR-200 family and CTCs in metastatic breast cancer before, during, and after a new line of systemic treatment |
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| Verf.angabe: | Chiara Fischer, Andrey Turchinovich, Manuel Feisst, Fabian Riedel, Kathrin Haßdenteufel, Philipp Scharli, Andreas D. Hartkopf, Sara Y. Brucker, Laura Michel, Barbara Burwinkel, Andreas Schneeweiss, Markus Wallwiener and Thomas M. Deutsch |
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| E-Jahr: | 2022 |
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| Jahr: | 23 August 2022 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 20.10.2022 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 23(2022), 17, Artikel-ID 9535, Seite 1-12 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | The extracellular circulating microRNA (miR)-200 regulates epithelial-mesenchymal transition and, thus, plays an essential role in the metastatic cascade and has shown itself to be a promising prognostic and predictive biomarker in metastatic breast cancer (MBC). Expression levels of the plasma miR-200 family were analyzed in relationship to systemic treatment, circulating tumor cells (CTC) count, progression-free survival (PFS), and overall survival (OS). Expression of miR-200a, miR-200b, miR-200c, miR-141, and miR-429, and CTC status (CTC-positive ≥ 5 CTC/7.5 mL) was assessed in 47 patients at baseline (BL), after the first completed cycle of a new line of systemic therapy (1C), and upon the progression of disease (PD). MiR-200a, miR-200b, and miR-141 expression was reduced at 1C compared to BL. Upon PD, all miR-200s were upregulated compared to 1C. At all timepoints, the levels of miR-200s were elevated in CTC-positive versus CTC-negative patients. Further, heightened miR-200s expression and positive CTC status were associated with poorer OS at BL and 1C. In MBC patients, circulating miR-200 family members decreased after one cycle of a new line of systemic therapy, were elevated during PD, and were indicative of CTC status. Notably, increased levels of miR-200s and elevated CTC count correlated with poorer OS and PFS. As such, both are promising biomarkers for optimizing the clinical management of MBC. |
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| DOI: | doi:10.3390/ijms23179535 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.3390/ijms23179535 |
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| | kostenfrei: Volltext: https://www.mdpi.com/1422-0067/23/17/9535 |
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| | DOI: https://doi.org/10.3390/ijms23179535 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | circulating microRNA |
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| | circulating tumor cells |
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| | CTC |
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| | EMT |
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| | epithelial-mesenchymal transition |
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| | MBC |
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| | metastatic breast cancer |
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| | microRNA-200 family |
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| | miR-200 family |
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| | miR-200s |
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| K10plus-PPN: | 1819460215 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Circulating miR-200 family and CTCs in metastatic breast cancer before, during, and after a new line of systemic treatment / Fischer, Chiara [VerfasserIn]; 23 August 2022 (Online-Ressource)
