Molecular analysis of Annexin expression in cancer

• Verfasst von: Hein, Tobias [VerfasserIn]
• Verfasst von: Krammer, Peter H. [VerfasserIn]
• Verfasst von: Weyd, Heiko [VerfasserIn]
• Titel: Molecular analysis of Annexin expression in cancer
• Verf.angabe: Tobias Hein, Peter H. Krammer and Heiko Weyd
• E-Jahr: 2022
• Jahr: 19 September 2022
• Umfang: 14 S.
• Fussnoten: Gesehen am 20.10.2022
• Titel Quelle: Enthalten in: BMC cancer
• Ort Quelle: London : BioMed Central, 2001
• Jahr Quelle: 2022
• Band/Heft Quelle: 22(2022), Artikel-ID 994, Seite 1-14
• ISSN Quelle: 1471-2407
• DOI: doi:10.1186/s12885-022-10075-8
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Annexins
• Sach-SW: Apoptotic cells
• Sach-SW: Immunosuppression
• Sach-SW: Peripheral tolerance
• Sach-SW: Tumour microenvironment
• K10plus-PPN: 1819467724

Abstract

Uptake of apoptotic cells induces a tolerogenic phenotype in phagocytes and promotes peripheral tolerance. The highly conserved Annexin core domain, present in all members of the Annexin family, becomes exposed on the apoptotic cell-surface and triggers tolerogenic signalling in phagocytes via the Dectin-1 receptor. Consequently, Annexins exposed on tumour cells upon cell death are expected to induce tolerance towards tumour antigens, inhibiting tumour rejection.