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Verfasst von:Stampfl, Ulrike [VerfasserIn]   i
 Radeleff, Boris [VerfasserIn]   i
 Sommer, Christof-Matthias [VerfasserIn]   i
 Stampfl, Sibylle [VerfasserIn]   i
 Dahlke, Angelika [VerfasserIn]   i
 Bellemann, Nadine [VerfasserIn]   i
 Kauczor, Hans-Ulrich [VerfasserIn]   i
 Richter, Götz Martin [VerfasserIn]   i
Titel:Midterm results of uterine artery embolization using narrow-size calibrated embozene microspheres
Verf.angabe:Ulrike Stampfl, Boris Radeleff, Christof Sommer, Sibylle Stampfl, Angelika Dahlke, Nadine Bellemann, Hans-Ulrich Kauczor, Goetz M. Richter
Jahr:2011
Umfang:11 S.
Fussnoten:Online veröffentlicht: 15 October 2010 ; Gesehen am 20.10.2022
Titel Quelle:Enthalten in: CardioVascular and interventional radiology
Ort Quelle:Berlin : Springer, 1978
Jahr Quelle:2011
Band/Heft Quelle:34(2011), 2, Seite 295-305
ISSN Quelle:1432-086X
Abstract:Purpose: To evaluate safety and efficacy of uterine artery embolization using narrow-size-range polyphosphazene-coated hydrogel microspheres (Embozene, CeloNova Biosciences, Newnan, GA). Methods: Between May 2006 and September 2008, a total of 121 consecutive patients (mean ± SD age 42.1 ± 5.4 years, range 30.5–51.5 years) were enrolled onto this single-center study. The primary study endpoint was safety as assessed by the society of interventional radiology (SIR) classification. The secondary endpoint was efficacy, which was based on a 1-year magnetic resonance imaging study and relief of symptoms documented by the Medical Outcomes Study 36-Item Short-Form Health Survey questionnaire over a 2-year interval. Results: The mean ± SD diameter of the dominant fibroid was 6.4 ± 2.6 (range, 2.9–13.9) cm and the mean volume 137.2 ± 245.1 (range, 5.3–1184) ml. Most patients had multiple fibroids with 11% more than 10. A total of 240 of 242 interventions were completed as planned, a technical success rate of 99.2%. According to the SIR classification, one type A, eight type C, and one type D complication occurred. Total devascularization was noted in 96% (116 of 121) of dominant fibroids. Volume decrease was 4% at 2 weeks, 52% (P < 0.001) at 3 months, 78% (P < 0.001) at 6 months, and 91% at 12 months (P < 0.001). The latter difference was statistically significant (P = 0.007). A total of 92% had improved hypermenorrhea at 1 year and 94% at 2 years. Dysmenorrhea was improved in 96% at 1 year and in 95% at 2 years. The overall health status score was 60.4 ± 26.2 points at baseline and 96.9 ± 3.8 after 1 year (P = 0.0019). Conclusion: Uterine artery embolization with Embozene microspheres is a safe procedure. Its efficacy is demonstrated by high fibroid devascularization and volume reduction rates and significant improvements of clinical symptoms and quality-of-life scores during follow-up.
DOI:doi:10.1007/s00270-010-9986-8
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/s00270-010-9986-8
 DOI: https://doi.org/10.1007/s00270-010-9986-8
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Fibroid devascularization
 Polyphosphazene-coated microspheres
 Quality of life
 Uterine artery embolization
 Uterine leiomyomata
K10plus-PPN:1819472434
Verknüpfungen:→ Zeitschrift

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