Vascularization in bioartificial parenchymal tissue

• Verfasst von: Salg, Gabriel Alexander [VerfasserIn]
• Verfasst von: Blaeser, Andreas [VerfasserIn]
• Verfasst von: Gerhardus, Jamina Sofie [VerfasserIn]
• Verfasst von: Hackert, Thilo [VerfasserIn]
• Verfasst von: Kenngott, Hannes Götz [VerfasserIn]
• Titel: Vascularization in bioartificial parenchymal tissue
• Titelzusatz: bioink and bioprinting strategies
• Verf.angabe: by Gabriel Alexander Salg, Andreas Blaeser, Jamina Sofie Gerhardus, Thilo Hackert and Hannes Goetz Kenngott
• E-Jahr: 2022
• Jahr: 2 August 2022
• Umfang: 25 S.
• Fussnoten: Gesehen am 21.10.2022
• Titel Quelle: Enthalten in: International journal of molecular sciences
• Ort Quelle: Basel : Molecular Diversity Preservation International, 2000
• Jahr Quelle: 2022
• Band/Heft Quelle: 23(2022), 15, Artikel-ID 8589, Seite 1-25
• ISSN Quelle: 1422-0067
• ISSN Quelle: 1661-6596
• DOI: doi:10.3390/ijms23158589
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1819620700
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Among advanced therapy medicinal products, tissue-engineered products have the potential to address the current critical shortage of donor organs and provide future alternative options in organ replacement therapy. The clinically available tissue-engineered products comprise bradytrophic tissue such as skin, cornea, and cartilage. A sufficient macro- and microvascular network to support the viability and function of effector cells has been identified as one of the main challenges in developing bioartificial parenchymal tissue. Three-dimensional bioprinting is an emerging technology that might overcome this challenge by precise spatial bioink deposition for the generation of a predefined architecture. Bioinks are printing substrates that may contain cells, matrix compounds, and signaling molecules within support materials such as hydrogels. Bioinks can provide cues to promote vascularization, including proangiogenic signaling molecules and cocultured cells. Both of these strategies are reported to enhance vascularization. We review pre-, intra-, and postprinting strategies such as bioink composition, bioprinting platforms, and material deposition strategies for building vascularized tissue. In addition, bioconvergence approaches such as computer simulation and artificial intelligence can support current experimental designs. Imaging-derived vascular trees can serve as blueprints. While acknowledging that a lack of structured evidence inhibits further meta-analysis, this review discusses an end-to-end process for the fabrication of vascularized, parenchymal tissue.