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 Online-Ressource | |
| Verfasst von: | Stevens, Kristen N. [VerfasserIn]  |
| Burwinkel, Barbara [VerfasserIn] | |
| Hamann, Ute [VerfasserIn] | |
| Chang-Claude, Jenny [VerfasserIn] | |
| Titel: | Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk |
| Verf.angabe: | K.N. Stevens, M. Garcia-Closas, Z. Fredericksen, M. Kosel, V.S. Pankratz, J.L. Hopper, G.S. Dite, C. Apicella, M.C. Southey, M.K. Schmidt, A. Broeks, L.J. Van ‘t Veer, R.a.E.M. Tollenaar, P.A. Fasching, M.W. Beckmann, A. Hein, A.B. Ekici, N. Johnson, J. Peto, I. dos Santos Silva, L. Gibson, E. Sawyer, I. Tomlinson, M.J. Kerin, S. Chanock, J. Lissowska, D.J. Hunter, R.N. Hoover, G.D. Thomas, R.L. Milne, J.I. Arias Pérez, A. González-Neira, J. Benítez, B. Burwinkel, A. Meindl, R.K. Schmutzler, C.R. Bartrar, U. Hamann, Y. D. Ko, T. Brüning, J. Chang-Claude, R. Hein, S. Wang-Gohrke, T. Dörk, P. Schürmann, M. Bremer, P. Hillemanns, N. Bogdanova, J.V. Zalutsky, Y.I. Rogov, N. Antonenkova, A. Lindblom, S. Margolin, A. Mannermaa, V. Kataja, V.-M. Kosma, J. Hartikainen, G. Chenevix-Trench, X. Chen, P. Peterlongo, B. Bonanni, L. Bernard, S. Manoukian, X. Wang, J. Cerhan, C.M. Vachon, J. Olson, G.G. Giles, L. Baglietto, C.A. McLean, G. Severi, E.M. John, A. Miron, R. Winqvist, K. Pylkäs, A. Jukkola-Vuorinen, M. Grip, I. Andrulis, J.A. Knight, G. Glendon, A.M. Mulligan, A. Cox, I.W. Brock, G. Elliott, S.S. Cross, P.P. Pharoah, A.M. Dunning, K.A. Pooley, M.K. Humphreys, J. Wang, D. Kang, K.-Y. Yoo, D.-Y. Noh, S. Sangrajrang, V. Gabrieau, P. Brennan, J. McKay, H. Anton-Culver, A. Ziogas, F.J. Couch and D.F. Easton the GENICA Network, kConFab Investigators, Australian Ovarian Cancer Study Group |
| E-Jahr: | 2011 |
| Jahr: | 27 October 2011 |
| Umfang: | 6 S. |
| Fussnoten: | Gesehen am 21.10.2022 |
| Titel Quelle: | Enthalten in: British journal of cancer |
| Ort Quelle: | Edinburgh : Nature Publ. Group, 1999 |
| Jahr Quelle: | 2011 |
| Band/Heft Quelle: | 105(2011), 12, Seite 1934-1939 |
| ISSN Quelle: | 1532-1827 |
| Abstract: | Background: Somatic mutations in phosphoinositide-3-kinase catalytic subunit alpha (PIK3CA) are frequent in breast tumours and have been associated with oestrogen receptor (ER) expression, human epidermal growth factor receptor-2 overexpression, lymph node metastasis and poor survival. The goal of this study was to evaluate the association between inherited variation in this oncogene and risk of breast cancer. Methods: A single-nucleotide polymorphism from the PIK3CA locus that was associated with breast cancer in a study of Caucasian breast cancer cases and controls from the Mayo Clinic (MCBCS) was genotyped in 5436 cases and 5280 controls from the Cancer Genetic Markers of Susceptibility (CGEMS) study and in 30 949 cases and 29 788 controls from the Breast Cancer Association Consortium (BCAC). Results: Rs1607237 was significantly associated with a decreased risk of breast cancer in MCBCS, CGEMS and all studies of white Europeans combined (odds ratio (OR)=0.97, 95% confidence interval (CI) 0.95–0.99, P=4.6 × 10−3), but did not reach significance in the BCAC replication study alone (OR=0.98, 95% CI 0.96–1.01, P=0.139). Conclusion: Common germline variation in PIK3CA does not have a strong influence on the risk of breast cancer. |
| DOI: | doi:10.1038/bjc.2011.448 |
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. Volltext ; Verlag: https://doi.org/10.1038/bjc.2011.448 |
| Volltext: https://www.nature.com/articles/bjc2011448 | |
| DOI: https://doi.org/10.1038/bjc.2011.448 | |
| Datenträger: | Online-Ressource |
| Sprache: | eng |
| Sach-SW: | Breast cancer |
| Cancer genetics | |
| Genetic predisposition to disease | |
| K10plus-PPN: | 1819636585 |
| Verknüpfungen: | → Zeitschrift |
