| |  Online-Ressource |
|---|
| Verfasst von: | Yeoh, Su-Ann [VerfasserIn]  |
|---|
| | Gianfrancesco, Milena [VerfasserIn] |
|---|
| | Lawson-Tovey, Saskia [VerfasserIn] |
|---|
| | Hyrich, Kimme L. [VerfasserIn] |
|---|
| | Strangfeld, Anja [VerfasserIn] |
|---|
| | Gossec, Laure [VerfasserIn] |
|---|
| | Carmona, Loreto [VerfasserIn] |
|---|
| | Mateus, Elsa F. [VerfasserIn] |
|---|
| | Schäfer, Martin [VerfasserIn] |
|---|
| | Richez, Christophe [VerfasserIn] |
|---|
| | Hachulla, Eric [VerfasserIn] |
|---|
| | Holmqvist, Marie [VerfasserIn] |
|---|
| | Scirè, Carlo Alberto [VerfasserIn] |
|---|
| | Lorenz, Hanns-Martin [VerfasserIn] |
|---|
| | Voll, Reinhard E. [VerfasserIn] |
|---|
| | Hasseli, Rebecca [VerfasserIn] |
|---|
| | Jayatilleke, Arundathi [VerfasserIn] |
|---|
| | Hsu, Tiffany Y.-T. [VerfasserIn] |
|---|
| | D’Silva, Kristin M. [VerfasserIn] |
|---|
| | Pimentel-Quiroz, Victor R. [VerfasserIn] |
|---|
| | Mercado, Monica Vasquez del [VerfasserIn] |
|---|
| | Shinjo, Samuel Katsuyuki [VerfasserIn] |
|---|
| | Neto, Edgard Torres dos Reis [VerfasserIn] |
|---|
| | Junior, Laurindo Ferreira da Rocha [VerfasserIn] |
|---|
| | Montandon, Ana Carolina de Oliveira e Silva [VerfasserIn] |
|---|
| | Pons-Estel, Guillermo J. [VerfasserIn] |
|---|
| | Ornella, Sofía [VerfasserIn] |
|---|
| | Exeni, Maria Eugenia D'Angelo [VerfasserIn] |
|---|
| | Velozo, Edson [VerfasserIn] |
|---|
| | Jordan, Paula [VerfasserIn] |
|---|
| | Sirotich, Emily [VerfasserIn] |
|---|
| | Hausmann, Jonathan S. [VerfasserIn] |
|---|
| | Liew, Jean W. [VerfasserIn] |
|---|
| | Jacobsohn, Lindsay [VerfasserIn] |
|---|
| | Gore-Massy, Monique [VerfasserIn] |
|---|
| | Sufka, Paul [VerfasserIn] |
|---|
| | Grainger, Rebecca [VerfasserIn] |
|---|
| | Bhana, Suleman [VerfasserIn] |
|---|
| | Wallace, Zachary [VerfasserIn] |
|---|
| | Robinson, Philip C. [VerfasserIn] |
|---|
| | Yazdany, Jinoos [VerfasserIn] |
|---|
| | Machado, Pedro M. [VerfasserIn] |
|---|
| Titel: | Factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy |
|---|
| Titelzusatz: | results from the COVID-19 Global Rheumatology Alliance physician-reported registry |
|---|
| Verf.angabe: | Su-Ann Yeoh, Milena Gianfrancesco, Saskia Lawson-Tovey, Kimme L. Hyrich, Anja Strangfeld, Laure Gossec, Loreto Carmona, Elsa F. Mateus, Martin Schäfer, Christophe Richez, Eric Hachulla, Marie Holmqvist, Carlo Alberto Scirè, Hanns-Martin Lorenz, Reinhard E. Voll, Rebecca Hasseli, Arundathi Jayatilleke, Tiffany Y.-T. Hsu, Kristin M. D’Silva, Victor R. Pimentel-Quiroz, Monica Vasquez del Mercado, Samuel Katsuyuki Shinjo, Edgard Torres dos Reis Neto, Laurindo Ferreira da Rocha Junior, Ana Carolina de Oliveira e Silva Montandon, Guillermo J. Pons-Estel, Sofía Ornella, Maria Eugenia D'Angelo Exeni, Edson Velozo, Paula Jordan, Emily Sirotich, Jonathan S. Hausmann, Jean W. Liew, Lindsay Jacobsohn, Monique Gore-Massy, Paul Sufka, Rebecca Grainger, Suleman Bhana, Zachary Wallace, Philip C. Robinson, Jinoos Yazdany, Pedro M. Machado, on behalf of the COVID-19 Global Rheumatology Alliance |
|---|
| E-Jahr: | 2022 |
|---|
| Jahr: | 13 September 2022 |
|---|
| Umfang: | 8 S. |
|---|
| Fussnoten: | Gesehen am 24.10.2022 |
|---|
| Titel Quelle: | Enthalten in: RMD Open |
|---|
| Ort Quelle: | London : BMJ Publishing Group, 2015 |
|---|
| Jahr Quelle: | 2022 |
|---|
| Band/Heft Quelle: | 8(2022), 2, Artikel-ID e002508, Seite 1-8 |
|---|
| ISSN Quelle: | 2056-5933 |
|---|
| Abstract: | Objectives To investigate factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy (IIM). - Methods Demographic data, clinical characteristics and COVID-19 outcome severity of adults with IIM were obtained from the COVID-19 Global Rheumatology Alliance physician-reported registry. A 3-point ordinal COVID-19 severity scale was defined: (1) no hospitalisation, (2) hospitalisation (and no death) and (3) death. ORs were estimated using multivariable ordinal logistic regression. Sensitivity analyses were performed using a 4-point ordinal scale: (1) no hospitalisation, (2) hospitalisation with no oxygen (and no death), (3) hospitalisation with oxygen/ventilation (and no death) and 4) death. - Results Of 348 patients, 48% were not hospitalised, 39% were hospitalised (and did not die) and 13% died. Older age (OR=1.59/decade, 95% CI 1.31 to 1.91), high disease activity (OR=3.50, 95% CI 1.25 to 9.83; vs remission), ≥2 comorbidities (OR=2.63, 95% CI 1.39 to 4.98; vs none), prednisolone-equivalent dose >7.5 mg/day (OR=2.40, 95% CI 1.09 to 5.28; vs no intake) and exposure to rituximab (OR=2.71, 95% CI 1.28 to 5.72; vs conventional synthetic disease-modifying antirheumatic drugs only) were independently associated with severe COVID-19. In addition to these variables, in the sensitivity analyses, male sex (OR range: 1.65-1.83; vs female) was also significantly associated with severe outcomes, while COVID-19 diagnosis after 1 October 2020 (OR range: 0.51-0.59; vs on/before 15 June 2020) was significantly associated with less severe outcomes, but these associations were not significant in the main model (OR=1.57, 95% CI 0.95 to 2.59; and OR=0.61, 95% CI 0.37 to 1.00; respectively). - Conclusions This is the first large registry data on outcomes of COVID-19 in people with IIM. Older age, male sex, higher comorbidity burden, high disease activity, prednisolone-equivalent dose >7.5 mg/day and rituximab exposure were associated with severe COVID-19. These findings will enable risk stratification and inform management decisions for patients with IIM. |
|---|
| DOI: | doi:10.1136/rmdopen-2022-002508 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1136/rmdopen-2022-002508 |
|---|
| | Volltext: https://rmdopen.bmj.com/content/8/2/e002508 |
|---|
| | DOI: https://doi.org/10.1136/rmdopen-2022-002508 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | COVID-19 |
|---|
| | dermatomyositis |
|---|
| | epidemiology |
|---|
| | outcome assessment, health care |
|---|
| | polymyositis |
|---|
| K10plus-PPN: | 1819763900 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy / Yeoh, Su-Ann [VerfasserIn]; 13 September 2022 (Online-Ressource)
