Stable precursor fragments of vasoactive peptides in umbilical cord blood of term and preterm infants

• Verfasst von: Koch, Lutz [VerfasserIn]
• Verfasst von: Dabek, Martin Thomas [VerfasserIn]
• Verfasst von: Frommhold, David [VerfasserIn]
• Verfasst von: Pöschl, Johannes [VerfasserIn]
• Titel: Stable precursor fragments of vasoactive peptides in umbilical cord blood of term and preterm infants
• Verf.angabe: L. Koch, M.T. Dabek, D. Frommhold, J. Poeschl
• E-Jahr: 2011
• Jahr: September 2, 2011
• Umfang: 6 S.
• Fussnoten: Gesehen am 24.10.2022
• Titel Quelle: Enthalten in: Hormone research in paediatrics
• Ort Quelle: Basel : Karger, 2010
• Jahr Quelle: 2011
• Band/Heft Quelle: 76(2011), 4, Seite 234-239
• ISSN Quelle: 1663-2826
• DOI: doi:10.1159/000329285
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1819768597

Abstract

Background: Though various neurohormonal systems are concurrently activated during birth, their biological effectors are not always easy to measure due to their short half-life in vivo, instability in biological samples, or very low concentrations. - Methods: Using a recently discovered chemiluminescence assay, we measured the stable precursor fragments mid-regional pro-atrial natriuretic peptide (MR-proANP), mid-regional pro-adrenomedullin (MR-proADM), C-terminal pro-endothelin-1 (CT-proET-1) and C-terminal pro-vasopressin (CT-proAVP or copeptin) immediately after birth in umbilical venous cord blood from 119 infants with a gestational age of 23-42 weeks and evaluated their possible functions. - Results: Cord blood levels of MR-proANP, MR- proADM, CT-proET-1, and CT-proAVP were considerably higher compared with normal adult levels. The CT-proAVP concentrations were 10-fold higher in term, and 70-fold higher in extremely preterm infants. MR-proANP showed 4-fold higher levels in term infants and 20-fold higher levels in extremely preterm infants. Levels of MR-proADM and CT-proET-1 were 2- to 3-fold higher in preterm and term infants. All four parameters showed significantly decreased values with increasing gestational age and a significant correlation between CT-proET-1 and MR-proADM. - Conclusion: Our results indicate that vasoactive and natriuretic mediators play a functionally relevant role in circulatory transition from fetal to neonatal life.