How HIV takes advantage of the cytoskeleton in entry and replication

• Verfasst von: Stolp-Rastätter, Bettina [VerfasserIn]
• Verfasst von: Fackler, Oliver Till [VerfasserIn]
• Titel: How HIV takes advantage of the cytoskeleton in entry and replication
• Verf.angabe: Bettina Stolp and Oliver T. Fackler
• E-Jahr: 2011
• Jahr: 28 March 2011
• Umfang: 19 S.
• Fussnoten: Gesehen am 24.10.2022
• Titel Quelle: Enthalten in: Viruses
• Ort Quelle: Basel : MDPI, 2009
• Jahr Quelle: 2011
• Band/Heft Quelle: 3(2011), 4, Seite 293-311
• ISSN Quelle: 1999-4915
• DOI: doi:10.3390/v3040293
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: actin cytoskeleton
• Sach-SW: cofilin
• Sach-SW: entry
• Sach-SW: HIV
• Sach-SW: Nef
• K10plus-PPN: 1819769046

Abstract

The host cell cytoskeleton plays a key role in the life cycle of viral pathogens whose propagation depends on mandatory intracellular steps. Accordingly, also the human immunodeficiency virus type 1 (HIV-1) has evolved strategies to exploit and modulate in particular the actin cytoskeleton for its purposes. This review will recapitulate recent findings on how HIV-1 hijacks the cytoskeleton to facilitate entry into, transport within and egress from host cells as well as to commandeer communication of infected with uninfected bystander cells.