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Verfasst von:Strauss, Ludwig G. [VerfasserIn]   i
 Pan, Leyun [VerfasserIn]   i
 Cheng, Caixia [VerfasserIn]   i
 Haberkorn, Uwe [VerfasserIn]   i
 Dimitrakopoulou-Strauss, Antonia [VerfasserIn]   i
Titel:Shortened acquisition protocols for the quantitative assessment of the 2-tissue-compartment model using dynamic PET/CT 18F-FDG studies
Verf.angabe:Ludwig G. Strauss, Leyun Pan, Caixia Cheng, Uwe Haberkorn, and Antonia Dimitrakopoulou-Strauss
E-Jahr:2011
Jahr:February 22, 2011
Umfang:7 S.
Fussnoten:Im Titel ist die Zahl 18 hochgestellt ; Gesehen am 24.10.2022
Titel Quelle:Enthalten in: Journal of nuclear medicine
Ort Quelle:New York, NY : Soc., 1964
Jahr Quelle:2011
Band/Heft Quelle:52(2011), 3, Seite 379-385
ISSN Quelle:2159-662X
 1535-5667
Abstract:18F-FDG kinetics are quantified by a 2-tissue-compartment model. The routine use of dynamic PET is limited because of this modality's 1-h acquisition time. We evaluated shortened acquisition protocols up to 0-30 min regarding the accuracy for data analysis with the 2-tissue-compartment model. Methods: Full dynamic series for 0-60 min were analyzed using a 2-tissue-compartment model. The time-activity curves and the resulting parameters for the model were stored in a database. Shortened acquisition data were generated from the database using the following time intervals: 0-10, 0-16, 0-20, 0-25, and 0-30 min. Furthermore, the impact of adding a 60-min uptake value to the dynamic series was evaluated. The datasets were analyzed using dedicated software to predict the results of the full dynamic series. The software is based on a modified support vector machines (SVM) algorithm and predicts the compartment parameters of the full dynamic series. Results: The SVM-based software provides user-independent results and was accurate at predicting the compartment parameters of the full dynamic series. If a squared correlation coefficient of 0.8 (corresponding to 80% explained variance of the data) was used as a limit, a shortened acquisition of 0-16 min was accurate at predicting the 60-min 2-tissue-compartment parameters. If a limit of 0.9 (90% explained variance) was used, a dynamic series of at least 0-20 min together with the 60-min uptake values is required. Conclusion: Shortened acquisition protocols can be used to predict the parameters of the 2-tissue-compartment model. Either a dynamic PET series of 0-16 min or a combination of a dynamic PET/CT series of 0-20 min and a 60-min uptake value is accurate for analysis with a 2-tissue-compartment model.
DOI:doi:10.2967/jnumed.110.079798
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.2967/jnumed.110.079798
 Volltext: https://jnm.snmjournals.org/content/52/3/379
 DOI: https://doi.org/10.2967/jnumed.110.079798
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:18F-FDG
 compartment modeling
 PET
 quantification
K10plus-PPN:1819776697
Verknüpfungen:→ Zeitschrift

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