Biochemical markers in the diagnosis of chondral defects following anterior cruciate ligament insufficiency

• Verfasst von: Streich, Nikolaus [VerfasserIn]
• Verfasst von: Zimmermann, David [VerfasserIn]
• Verfasst von: Schmitt, Holger [VerfasserIn]
• Verfasst von: Bode, Gerrit [VerfasserIn]
• Titel: Biochemical markers in the diagnosis of chondral defects following anterior cruciate ligament insufficiency
• Verf.angabe: Nikolaus A. Streich, David Zimmermann, Holger Schmitt, Gerrit Bode
• E-Jahr: 2011
• Jahr: 11 January 2011
• Umfang: 5 S.
• Fussnoten: Gesehen am 24.10.2022
• Titel Quelle: Enthalten in: International orthopaedics
• Ort Quelle: Berlin : Springer, 1977
• Jahr Quelle: 2011
• Band/Heft Quelle: 35(2011), 11, Seite 1633-1637
• ISSN Quelle: 1432-5195
• DOI: doi:10.1007/s00264-010-1191-5
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Anterior Cruciate Ligament
• Sach-SW: Anterior Cruciate Ligament Rupture
• Sach-SW: Cartilage Degradation
• Sach-SW: Cartilage Oligomeric Matrix Protein
• Sach-SW: Cartilage Volume
• K10plus-PPN: 1819784320

Abstract

Purpose: The aim of this study was to determine the value of systemic biochemical markers of bone turnover—urine levels of cross-linked C-terminal telopeptide I (uCTX-I), urinary C-terminal telopeptide II (uCTX-II) and serum cartilage oligomeric matrix protein (sCOMP)—in the diagnosis of chondral defects after anterior cruciate ligament (ACL) rupture. Thirty-eight patients with previous ACL rupture were included. Methods: Magnetic resonance imaging (MRI) of the injured and the intact knee joint was performed with volumetric measurement of volume and area of cartilage (VC/AC), area of subchondral bone (cAB), and area of subchondral bone denuded and eroded (dAB). Biochemical markers were measured using commercially available enzyme-linked immunoassays. Results: MRI-based volumetric cartilage measurement showed significant differences between the injured and the intact knees. uCTX-I, sCOMP and in parts uCTX-II correlated well with MRI parameters. CTX-I showed a significant correlation with VC and AC of the whole knee joint. Conclusions: The results suggest that uCTX-I, uCTX-II and sCOMP could identify patients with focal cartilage lesions from an early stage of osteoarthritis of the knee.