Status: Bibliographieeintrag
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| Verfasst von: | Schnitzler, Paul [VerfasserIn]  |
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| | Schulz, K. [VerfasserIn] |
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| | Lampson, Christian [VerfasserIn] |
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| | Geiss, M. [VerfasserIn] |
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| | Geiss, Heinrich K. [VerfasserIn] |
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| Titel: | Molecular analysis of linezolid resistance in clinical Enterococcus faecium isolates by polymerase chain reaction and pyrosequencing |
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| Verf.angabe: | P. Schnitzler, K. Schulz, C. Lampson, M. Geiss, H. K. Geiss |
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| E-Jahr: | 2011 |
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| Jahr: | [2011] |
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| Umfang: | 5 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Published: 03 September 2010 ; Gesehen am 25.10.2022 |
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| Titel Quelle: | Enthalten in: European journal of clinical microbiology & infectious diseases |
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| Ort Quelle: | Berlin : Springer, 1982 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 30(2011), 1, Seite 121-125 |
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| ISSN Quelle: | 1435-4373 |
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| Abstract: | Resistance to linezolid has been associated with a G2576T mutation in the 23 S rRNA gene. Clinical isolates of linezolid-sensitive and linezolid-resistant vancomycin-resistant Enterococcus faecium of a liver transplant patient have been analysed for the G2576T mutation by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP), conventional sequencing and pyrosequencing. A clear association between the number of mutated 23 S rRNA genes and the level of linezolid resistance has been demonstrated. Linezolid susceptibility re-emerged after cessation of linezolid therapy; however, the re-initiation of linezolid therapy resulted in the re-emergence of linezolid-resistant strains. Pyrosequencing rapidly detected the number of mutated alleles and is superior to conventional PCR-RFLP for the detection of heterozygous mutations. |
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| DOI: | doi:10.1007/s10096-010-1046-4 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s10096-010-1046-4 |
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| | DOI: https://doi.org/10.1007/s10096-010-1046-4 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Clinical Isolate |
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| | Linezolid |
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| | Linezolid Therapy |
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| | Peptidyl Transferase Centre |
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| | Polymerase Chain Reaction Restriction Fragment Length Polymorphism |
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| K10plus-PPN: | 1819852784 |
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| Verknüpfungen: | → Zeitschrift |
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Molecular analysis of linezolid resistance in clinical Enterococcus faecium isolates by polymerase chain reaction and pyrosequencing / Schnitzler, Paul [VerfasserIn]; [2011] (Online-Ressource)
68978013
