Relative biological effectiveness of carbon ions for local tumor control of a radioresistant prostate carcinoma in the rat

• Verfasst von: Peschke, Peter [VerfasserIn]
• Verfasst von: Karger, Christian [VerfasserIn]
• Verfasst von: Scholz, Michael [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Verfasst von: Huber, Peter E. [VerfasserIn]
• Titel: Relative biological effectiveness of carbon ions for local tumor control of a radioresistant prostate carcinoma in the rat
• Verf.angabe: Peter Peschke, PH.D., Christian P. Karger, PH.D., Michael Scholz, PH.D., Jürgen Debus, M.D., PH.D., Peter E. Huber, M.D., PH.D.
• Jahr: 2011
• Umfang: 8 S.
• Fussnoten: Available online 8 October 2010 ; Gesehen am 25.10.2022
• Titel Quelle: Enthalten in: International journal of radiation oncology, biology, physics
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1975
• Jahr Quelle: 2011
• Band/Heft Quelle: 79(2011), 1, Seite 239-246
• ISSN Quelle: 1879-355X
• DOI: doi:10.1016/j.ijrobp.2010.07.1976
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Adenocarcinoma
• Sach-SW: Animals
• Sach-SW: Carbon
• Sach-SW: Cell Line, Tumor
• Sach-SW: Male
• Sach-SW: Photons
• Sach-SW: Prostatic Neoplasms
• Sach-SW: Radiation Injuries, Experimental
• Sach-SW: Radiation Tolerance
• Sach-SW: Radiation, Ionizing
• Sach-SW: Radiodermatitis
• Sach-SW: Rats
• Sach-SW: Relative Biological Effectiveness
• Sach-SW: Skin
• Sach-SW: Tumor Burden
• Sach-SW: Xenograft Model Antitumor Assays
• K10plus-PPN: 1819909492

Abstract

PURPOSE: To study the relative biological effectiveness (RBE) of carbon ion beams relative to X-rays for local tumor control in a syngeneic rat prostate tumor (Dunning subline R3327-AT1). - METHODS AND MATERIALS: A total of 198 animals with tumors in the distal thigh were treated with increasing single and split doses of either (12)C ions or photons using a 20-mm spread-out Bragg peak. Endpoints of the study were local control (no tumor recurrence within 300 days) and volumetric changes after irradiation. The resulting values for D(50) (dose at 50% tumor control probability) were used to determine RBE values. - RESULTS: The D(50) values for single doses were 32.9 ± 0.9 Gy for (12)C ions and 75.7 ± 1.6 Gy for photons. The respective values for split doses were 38.0 ± 2.3 Gy and 90.6 ± 2.3 Gy. The corresponding RBE values were 2.30 ± 0.08 for single and 2.38 ± 0.16 for split doses. The most prominent side effects were dry and moist desquamation of the skin, which disappeared within weeks. - CONCLUSION: The study confirmed the effectiveness of carbon ion therapy for severely radioresistant tumors. For 1- and 2-fraction photon and (12)C ion radiation, we have established individual D(50) values for local tumor control as well as related RBE values.