Experimental imaging of asthma progression and therapeutic response in mouse lung models

• Verfasst von: Dullin, Christian [VerfasserIn]
• Titel: Experimental imaging of asthma progression and therapeutic response in mouse lung models
• Mitwirkende: Stühmer, Walter [AkademischeR BetreuerIn]
• Mitwirkende: Stühmer, Walter [GutachterIn]
• Mitwirkende: Fuchs, Eberhard [GutachterIn]
• Verf.angabe: vorgelegt von Christian Dullin
• Verlagsort: Göttingen
• Jahr: 2015
• Umfang: 1 Online-Ressource
• Illustrationen: Illustrationen, Diagramme
• Hochschulschrift: Dissertation, Georg-August-Universität Göttingen, 2015
• URN: urn:nbn:de:gbv:7-11858/00-1735-0000-0023-9670-7-4
• Datenträger: Online-Ressource
• Dokumenttyp: Hochschulschrift
• Sprache: eng
• K10plus-PPN: 1031796894

Abstract

Mouse models have been a versatile tool in asthma research, however the application of imaging techniques to quantify hallmarks of asthma, to follow the course of the disease or to monitor treatment response are hampered by the small size of the mouse lung. Moreover, breathing causes substantial motion artifacts in most of the in-vivo imaging methods. In addition, the air-tissue interfaces within the lung causes scattering effects in optical imaging applications, the large cavity of the lung leads to susceptibility artifacts in magnetic resonance imaging and the rib cage hinders the use of ...