Posttransplant sCD30 as a predictor of kidney graft outcome

• Verfasst von: Süsal, Caner [VerfasserIn]
• Verfasst von: Döhler, Bernd [VerfasserIn]
• Verfasst von: Sadeghi, Mahmoud [VerfasserIn]
• Verfasst von: Salmela, Kaija T. [VerfasserIn]
• Verfasst von: Weimer, Rolf [VerfasserIn]
• Verfasst von: Zeier, Martin [VerfasserIn]
• Verfasst von: Opelz, Gerhard [VerfasserIn]
• Titel: Posttransplant sCD30 as a predictor of kidney graft outcome
• Verf.angabe: Caner Süsal, Bernd Döhler, Mahmoud Sadeghi, Kaija T. Salmela, Rolf Weimer, Martin Zeier, and Gerhard Opelz
• E-Jahr: 2011
• Jahr: June 27, 2011
• Umfang: 6 S.
• Fussnoten: Gesehen am 26.10.2022
• Titel Quelle: Enthalten in: Transplantation
• Ort Quelle: Hagerstown, Md. : Lippincott Williams & Wilkins, 1963
• Jahr Quelle: 2011
• Band/Heft Quelle: 91(2011), 12, Seite 1364-1369
• ISSN Quelle: 1534-6080
• DOI: doi:10.1097/TP.0b013e31821aba74
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 182002296X

Abstract

Background. - Reliable markers for assessing the biological effect of immunosuppressive drugs and identification of transplant recipients at risk of developing rejection are not available. - Methods. - In a prospective multicenter study, we investigated whether posttransplant measurement of the T-cell activation marker soluble CD30 (sCD30) can be used for estimating the risk of graft loss in kidney transplant recipients. Pre- and posttransplant sera of 2322 adult deceased-donor kidney recipients were tested for serum sCD30 content using a commercial enzyme-linked immunosorbent assay. - Results. - sCD30 decreased posttransplant and reached a nadir on day 30. Patients with a high sCD30 of more than or equal to 40 U/mL on day 30 showed a subsequent graft survival rate after 3 years of 78.3±4.1%, significantly lower than the 90.3±1.0% rate in recipients with a low sCD30 on day 30 of less than 40 U/mL (log-rank P<0.001; Cox hazard ratio 2.02, P<0.001). Although an association was found between pre- and posttransplant sCD30 levels, patients with high sCD30 on posttransplant day 30 demonstrated significantly lower 3-year graft survival irrespective of the pretransplant level. - Conclusions. - Our data suggest that posttransplant measurement of sCD30 on day 30 is a predictor of subsequent graft loss in kidney transplant recipients and that sCD30 may potentially serve as an indicator for adjustment of immunosuppressive medication.