| |  Online-Ressource |
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| Verfasst von: | Rommel, Marcel G. E. [VerfasserIn]  |
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| | Walz, Lisa [VerfasserIn] |
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| | Fotopoulou, Foteini [VerfasserIn] |
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| | Kohlscheen, Saskia [VerfasserIn] |
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| | Schenk, Franziska [VerfasserIn] |
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| | Miskey, Csaba [VerfasserIn] |
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| | Botezatu, Lacramioara [VerfasserIn] |
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| | Krebs, Yvonne [VerfasserIn] |
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| | Voelker, Iris M. [VerfasserIn] |
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| | Wittwer, Kevin [VerfasserIn] |
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| | Holland-Letz, Tim [VerfasserIn] |
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| | Ivics, Zoltán [VerfasserIn] |
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| | von Messling, Veronika [VerfasserIn] |
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| | Essers, Marieke A. G. [VerfasserIn] |
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| | Milsom, Michael [VerfasserIn] |
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| | Pfaller, Christian K. [VerfasserIn] |
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| | Modlich, Ute [VerfasserIn] |
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| Titel: | Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output |
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| Verf.angabe: | Marcel G.E. Rommel, Lisa Walz, Foteini Fotopoulou, Saskia Kohlscheen, Franziska Schenk, Csaba Miskey, Lacramioara Botezatu, Yvonne Krebs, Iris M. Voelker, Kevin Wittwer, Tim Holland-Letz, Zoltán Ivics, Veronika von Messling, Marieke A.G. Essers, Michael D. Milsom, Christian K. Pfaller, and Ute Modlich |
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| E-Jahr: | 2022 |
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| Jahr: | October 4, 2022 |
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| Umfang: | 18 S. |
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| Fussnoten: | Gesehen am 26.10.2022 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 41(2022), 1, Artikel-ID 111447, Seite 1-18 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Respiratory tract infections are among the deadliest communicable diseases worldwide. Severe cases of viral lung infections are often associated with a cytokine storm and alternating platelet numbers. We report that hematopoietic stem and progenitor cells (HSPCs) sense a non-systemic influenza A virus (IAV) infection via inflammatory cytokines. Irrespective of antiviral treatment or vaccination, at a certain threshold of IAV titer in the lung, CD41-positive hematopoietic stem cells (HSCs) enter the cell cycle while endothelial protein C receptor-positive CD41-negative HSCs remain quiescent. Active CD41-positive HSCs represent the source of megakaryocytes, while their multi-lineage reconstitution potential is reduced. This emergency megakaryopoiesis is thrombopoietin independent and attenuated in IAV-infected interleukin-1 receptor-deficient mice. Newly produced platelets during IAV infection are immature and hyper-reactive. After viral clearance, HSC quiescence is re-established. Our study reveals that non-systemic viral respiratory infection has an acute impact on HSCs via inflammatory cytokines to counteract IAV-induced thrombocytopenia. |
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| DOI: | doi:10.1016/j.celrep.2022.111447 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2022.111447 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2211124722012888 |
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| | DOI: https://doi.org/10.1016/j.celrep.2022.111447 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cytokines |
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| | emergency megakaryopoiesis |
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| | hematopoietic stem cell activation |
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| | inflammation |
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| | influenza |
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| | platelet activation |
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| | respiratory virus infection |
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| | vaccination |
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| K10plus-PPN: | 1820053105 |
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| Verknüpfungen: | → Zeitschrift |
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Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output / Rommel, Marcel G. E. [VerfasserIn]; October 4, 2022 (Online-Ressource)
