| Online-Ressource |
Verfasst von: | Rommel, Marcel G. E. [VerfasserIn]  |
| Walz, Lisa [VerfasserIn]  |
| Fotopoulou, Foteini [VerfasserIn]  |
| Kohlscheen, Saskia [VerfasserIn]  |
| Schenk, Franziska [VerfasserIn]  |
| Miskey, Csaba [VerfasserIn]  |
| Botezatu, Lacramioara [VerfasserIn]  |
| Krebs, Yvonne [VerfasserIn]  |
| Voelker, Iris M. [VerfasserIn]  |
| Wittwer, Kevin [VerfasserIn]  |
| Holland-Letz, Tim [VerfasserIn]  |
| Ivics, Zoltán [VerfasserIn]  |
| von Messling, Veronika [VerfasserIn]  |
| Essers, Marieke A. G. [VerfasserIn]  |
| Milsom, Michael [VerfasserIn]  |
| Pfaller, Christian K. [VerfasserIn]  |
| Modlich, Ute [VerfasserIn]  |
Titel: | Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output |
Verf.angabe: | Marcel G.E. Rommel, Lisa Walz, Foteini Fotopoulou, Saskia Kohlscheen, Franziska Schenk, Csaba Miskey, Lacramioara Botezatu, Yvonne Krebs, Iris M. Voelker, Kevin Wittwer, Tim Holland-Letz, Zoltán Ivics, Veronika von Messling, Marieke A.G. Essers, Michael D. Milsom, Christian K. Pfaller, and Ute Modlich |
E-Jahr: | 2022 |
Jahr: | October 4, 2022 |
Umfang: | 18 S. |
Fussnoten: | Gesehen am 26.10.2022 |
Titel Quelle: | Enthalten in: Cell reports |
Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
Jahr Quelle: | 2022 |
Band/Heft Quelle: | 41(2022), 1, Artikel-ID 111447, Seite 1-18 |
ISSN Quelle: | 2211-1247 |
Abstract: | Respiratory tract infections are among the deadliest communicable diseases worldwide. Severe cases of viral lung infections are often associated with a cytokine storm and alternating platelet numbers. We report that hematopoietic stem and progenitor cells (HSPCs) sense a non-systemic influenza A virus (IAV) infection via inflammatory cytokines. Irrespective of antiviral treatment or vaccination, at a certain threshold of IAV titer in the lung, CD41-positive hematopoietic stem cells (HSCs) enter the cell cycle while endothelial protein C receptor-positive CD41-negative HSCs remain quiescent. Active CD41-positive HSCs represent the source of megakaryocytes, while their multi-lineage reconstitution potential is reduced. This emergency megakaryopoiesis is thrombopoietin independent and attenuated in IAV-infected interleukin-1 receptor-deficient mice. Newly produced platelets during IAV infection are immature and hyper-reactive. After viral clearance, HSC quiescence is re-established. Our study reveals that non-systemic viral respiratory infection has an acute impact on HSCs via inflammatory cytokines to counteract IAV-induced thrombocytopenia. |
DOI: | doi:10.1016/j.celrep.2022.111447 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2022.111447 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S2211124722012888 |
| DOI: https://doi.org/10.1016/j.celrep.2022.111447 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | cytokines |
| emergency megakaryopoiesis |
| hematopoietic stem cell activation |
| inflammation |
| influenza |
| platelet activation |
| respiratory virus infection |
| vaccination |
K10plus-PPN: | 1820053105 |
Verknüpfungen: | → Zeitschrift |
Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output / Rommel, Marcel G. E. [VerfasserIn]; October 4, 2022 (Online-Ressource)